» Investigación » SISIUS - Investigación en la USE

Mohammed Rafii-El-Idrissi Benhnia
Telefono: 955923109
Email: Solicitar correo
Perfil en ORCID: 0000-0001-7405-9476
Perfil en ResearcherID: F-3019-2015
Perfil en Scopus: 6603261906
Otro enlace a Web de investigación: http://www.ibis-sevilla.es/investigacion/enfermedades-infecciosas-y-del-sistema-inmunitario/inmunovirologia/leal-noval-manuel.aspx

Grupo de Investigación: CTS-590 Inmunovirologia
Departamento/Unidad: Bioquímica Médica y Biología Molecular e Inmunología
Situación profesional: Profesor Contratado Doctor

Responsable de los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Nuevos atributos funcionales de las células T CD4 foliculares VIH especificas en el control espontáneo del VIH en individuos controladores de elite (US-1380938)
  • Predicción de la respuesta de anticuerpos altamente neutralizante y control del VIH en la colaboración de células TCD4+ (TFH) y ausencia de disfunciones de linfocitos B (PI13/01836)
  
  
• Ayuda a la investigación:
  • Nuevos Métodos para Erradicar el VIH y Aumentar la Respuesta Inmune a la Vacuna del VHB Usando Redes Metal Orgánicas como Agentes Encapsulantes (PP2020/IV.4/06)
  • Papel de las células T CD4+ foliculares circulantes y de linfocitos B en la mejora de la inmunidad humoral y el control espontáneo del VIH en individuos controladores de elite/Biomedicina (Salud (PP2018-10404)
  
  

Participa en los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Encapsulating agents based on the use of metal organic frameworks as new approaching to eradicate HIV (P20_01234 - Equipo de Investigación)
  
  
• Contrato con empresas (Arts. 68/83 LOU):
  • Role of a combined antiretroviral treatment including maraviroc in the response to hepatitis B and A virus vaccine. (2808/0831 - Otro Investigador)
  
  

Cobertura de la base de datos de proyectos, véase aqui

Publicaciones:

Capítulos en Libros

Ostos Marcos, Francisco José, Martínez , Laura, Rafii-el-Idrissi Benhnia, Mohammed:
Innovación Docente en Bioquímica: Nuevas Perspectivas en el Desarrollo de Podcasts Como una Herramienta de Aprendizaje en la Universidad de Sevilla. Pag. 1400-1408. En: Enseñanza e innovación educativa en el ámbito universitario. Dykinson. 2024. ISBN 978-84-1070-018-5

Perez Puyana, Víctor Manuel, Ostos Marcos, Francisco José, Rafii-el-Idrissi Benhnia, Mohammed, Paz Bañez, Maria Violante de, Romero García, Alberto:
Aplicación de un Abp en Carreras Científicas. Pag. 681-688. En: Mejorando la Enseñanza a Través de la Innovación Educativa. Madrid, España. Dykinson, S.L. 2023. 968. ISBN 978-84-1122-686-8

Rafii-el-Idrissi Benhnia, Mohammed:
Mechanisms of action of melatonin on the human immune system. Membranes versus Nuclear receptors. En: Frontiers of Hormone Research, Therapeutic potential of the Pineal Hormone Melatonin. Karger Medical and Scientific Publishers. 1997. ISBN 978-3-8055-6439-7

Rafii-el-Idrissi Benhnia, Mohammed:
Mechanisms of action of melatonin on the human immune system. Vol. 23. Pag. 43-51. En: Frontiers of Hormone Research, Therapeutic potential of the Pineal Hormone Melatonin. Karger Medical and Scientific Publishers. 1997. ISBN 978-3-8055-6439-7

Rafii-el-Idrissi Benhnia, Mohammed:
Mechanisms of action of melatonin on the human immune system. Membranes versus Nuclear receptors. Pag. 43-52. En: Frontiers of Hormone Research, Therapeutic Potential of Melatonin. Basilea (Suiza). Karger. 1996

Publicaciones en Revistas

Sánchez-Cid Bueno, Pablo, Alonso González, María, Jiménez Rosado, Mercedes, Rafii-el-Idrissi Benhnia, Mohammed, Ruiz Mateos Carmona, Ezequiel, et. al.:
Effect of different crosslinking agents on hybrid chitosan/collagen hydrogels for potential tissue engineering applications. En: International Journal of Biological Macromolecules. 2024. Vol. 263. Núm. 2. https://doi.org/10.1016/j.ijbiomac.2024.129858

Sánchez-Cid Bueno, Pablo, González, Gabriel, Alonso González, María, Jiménez Rosado, Mercedes, Rafii-el-Idrissi Benhnia, Mohammed, et. al.:
Influence of natural crosslinkers on chitosan hydrogels for potential biomedical applications. En: Macromolecular Materials and Engineering. 2023. Vol. 308. https://doi.org/10.1002/mame.202300195

Ostos Marcos, Francisco José, Martínez Santa, Marta, Lebrón Romero, José Antonio, García, Francisco Javier, Bernal Perez, Eva, et. al.:
Meeting-Abstract: Biocompatible systems as a promising approach for eradicating HIV reservoirs ex vivo. En: FEBS Open Bio. 2023. Vol. 13. Núm. S1. Pag. 3-72. 10.1002/2211-5463.13608

González Ulloa, Gabriel, Jiménez Rosado, Mercedes, Rafii-el-Idrissi Benhnia, Mohammed, Romero García, Alberto, Ruiz Mateos Carmona, Ezequiel, et. al.:
Hybrid Polymeric Hydrogel-based Biomaterials with Potential Applications in Regenerative Medicine. En: Journal of Molecular Liquids. 2023. Vol. 384. 10.1016/j.molliq.2023.122224

Mehdi Sefiani, Hanaa, Perez Puyana, Víctor Manuel, Ostos Marcos, Francisco José, Sepúlveda Ferrer, Ranier, Romero García, Alberto, et. al.:
Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery. En: Polymers. 2023. Vol. 15. Núm. 2. 10.3390/polym15020275

Vitallé, Joana, Pérez Gómez, A., Ostos Marcos, Francisco José, Gasca, María del Carmen, Jimenez, Maria Reyes, et. al.:
Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people. En: JCI Insight. 2022. Vol. 7. Núm. 17. 10.1172/jci.insight.161045

Espíndola, Cecilia, Correa, Alejandro Javier, Lopez Lopez, Manuel, Lopez Cornejo, María del Pilar, Bernal Perez, Eva, et. al.:
Single -and Multi-Walled Carbon Nanotubes as Nanocarriers for the Delivery of 7-Hydroxyflavone. En: Pharmaceutics. 2022. Vol. 14. Núm. 12. 10.3390/pharmaceutics14122806

Pérez Gómez, A., Gasca, María del Carmen, Vitallé, Joana, Ostos Marcos, Francisco José, Trujillo, María, et. al.:
Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response. En: Clinical and Translational Medicine. 2022. Vol. 12. Núm. 4. 10.1002/ctm2.802

Sánchez-Cid Bueno, Pablo, Jiménez Rosado, Mercedes, Rubio , José Fernando, Romero García, Alberto, Ostos Marcos, Francisco José, et. al.:
Biocompatible and Thermoresistant Hydrogels Based on Collagen and Chitosan. En: Polymers. 2022. Vol. 14. https://doi.org/ 10.3390/polym14020272

Rafii-el-Idrissi Benhnia, Mohammed:
Phenotype and Polyfunctional Deregulation Involving Interleukin 6 (IL-6)¿ and IL-10¿Producing Monocytes in HIV-Infected Patients Receiving Combination Antiretroviral Therapy Differ From Those in Healthy Older Individuals. En: The Journal of Infectious Diseases. 2016. Vol. 213. Núm. 6. Pag. 999-1007. https://doi.org/10.1093/infdis/jiv520

Méndez Lagares, Gema, Rafii-el-Idrissi Benhnia, Mohammed:
Maraviroc contributes to the restoration of the homeostasis of regulatory T-cell subsets in antiretroviral-naive HIV-infected subjects. En: Clinical Microbiology and Infection. 2016. Vol. 22. Núm. 5. Pag. 461. e1-461. e5-461. e1-461. e5. https://doi.org/10.1016/j.cmi.2015.12.025

Rafii-el-Idrissi Benhnia, Mohammed:
Immunovirological Efficacy of Once-Daily Maraviroc Plus Ritonavir-Boosted Atazanavir After 48 Weeks in Naive HIV-Infected Patients. En: Viral Immunology. 2016. Vol. 29. Núm. 8. Pag. 471-477. 10.1089/vim.2016.0046

De Pablo Bernal, Rebeca, Cañizares, Julio, Rosado, Isaac, Galvá, María Isabel, Álvarez Ríos, Ana Isabel, et. al.:
Monocyte Phenotype and Polyfunctionality Are Associated With Elevated Soluble Inflammatory Markers, Cytomegalovirus Infection, and Functional and Cognitive Decline in Elderly Adults. En: The Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 2016. Vol. Oct;66. Núm. 5. Pag. 643-652. 10.1093/gerona/glv121

Rafii-el-Idrissi Benhnia, Mohammed:
IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals. En: Clinical Microbiology and Infection. 2015. Vol. 21. Núm. 3. Pag. 289.e1-4-289.e1-4. 10.1016/j.cmi.2014.10.012

Rafii-el-Idrissi Benhnia, Mohammed:
Maraviroc Clinical Test (MCT) as an alternative tool to decide CCR5-antagonists prescription in naïve HIV-infected patients. En: Antiviral Research. 2015. Vol. 121. Pag. 94-96. https://doi.org/10.1016/j.antiviral.2015.06.018

Rafii-el-Idrissi Benhnia, Mohammed:
Structural and functional characterization of anti-A33 antibodies reveal a potent cross-species orthopoxviruses neutralizer. En: PLoS Pathogens. 2015. Vol. 11. Núm. 9. 10.1371/journal.ppat.1005148

Rafii-el-Idrissi Benhnia, Mohammed:
Using a Combined Computational-Experimental Approach to Predict Antibody-Specific B Cell Epitopes. En: Structure. 2014. Vol. 22. Núm. 4. Pag. 646-657. 10.1016/j.str.2014.02.003

Romero Sánchez, Maria Concepción, Álvarez Ríos, Ana Isabel, Bernal Morell, e, Genebat, Manuel, Vera, F, et. al.:
Maintenance of virologic efficacy and decrease in levels of beta2-microglobulin, soluble CD40L and soluble CD14 after switching previously treated HIV-infected patients to an NRTI-sparing dual therapy. En: Antiviral Research. 2014. Vol. 111. Pag. 26-32. 10.1016/j.antiviral.2014.08.011

Rafii-el-Idrissi Benhnia, Mohammed:
Editorial: The Challenge of Poxvirus Resistance to Antibody Neutralization. En: Journal of Virology. 2013. Vol. Feb (87). Núm. 3. Pag. 1289-1289. 10.1128/Jvi.02152-12

Rafii-el-Idrissi Benhnia, Mohammed:
Unusual features of vaccinia virus extracellular virion form neutralization resistance revealed in human antibody responses to the smallpox vaccine. En: Journal of Virology. 2013. Vol. 87. Núm. 3. Pag. 1569-1585. 10.1128/Jvi.02152-12

Rafii-el-Idrissi Benhnia, Mohammed:
Structural and biochemical characterization of the vaccinia virus envelope protein D8 and its recognition by the antibody LA5. En: Journal of Virology. 2012. Vol. 86. Núm. 15. Pag. 8050-8058. 10.1128/Jvi.00836-12

Rafii-el-Idrissi Benhnia, Mohammed:
B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus. En: The Journal of Immunology. 2011. Vol. 186. Núm. 9. Pag. 5294-5303. 10.4049/jimmunol.1100406

Rafii-el-Idrissi Benhnia, Mohammed:
Combination therapy of vaccinia virus infection with human anti-H3 and anti-B5 monoclonal antibodies in a small animal model. En: Antiviral Therapy. 2010. Vol. 15. Núm. 4. Pag. 661-675. 10.3851/Imp1573

Rafii-el-Idrissi Benhnia, Mohammed:
Vaccinia virus extracellular enveloped virion neutralization in vitro and protection in vivo depend on complement. En: Journal of Virology. 2009. Vol. 83. Núm. 3. Pag. 1201-1215. 10.1128/Jvi.01797-08

Rafii-el-Idrissi Benhnia, Mohammed:
Heavily Isotype Dependent Protective Activities of Human Antibodies Against the Vaccinia Virus Extracellular Virion Antigen B5. En: Journal of Virology. 2009. Vol. 83. Núm. 23. Pag. 12355-12367. 10.1128/Jvi.01593-09

Rafii-el-Idrissi Benhnia, Mohammed:
Redundancy and plasticity of neutralizing antibody responses are cornerstone attributes of the human immune response to the smallpox vaccine. En: Journal of Virology. 2008. Vol. 82. Núm. 7. Pag. 3751-3768. 10.1128/Jvi.02244-07

Rafii-el-Idrissi Benhnia, Mohammed:
Selective CD4 T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. En: Immunity. 2008. Vol. 28. Núm. 6. Pag. 847-858. 10.1016/j.immuni.2008.04.018

Rafii-el-Idrissi Benhnia, Mohammed:
NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi. En: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2008. Vol. 105. Núm. 50. Pag. 19863-19868. 10.1073/pnas.0810519105.

Rafii-el-Idrissi Benhnia, Mohammed:
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. En: Nature Immunology. 2006. Vol. 7. Núm. 9. Pag. 978-986. 10.1038/ni1380

Rafii-el-Idrissi Benhnia, Mohammed:
Signaling through CD14 attenuates the inflammatory response to Borrelia burgdorferi, the agent of Lyme disease. En: The Journal of Immunology. 2005. Vol. 174. Núm. 3. Pag. 1539-1548. 10.4049/jimmunol.174.3.1539

Rafii-el-Idrissi Benhnia, Mohammed:
Characterization of membrane melatonin receptor in mouse peritoneal macrophages: Inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. En: Journal of Neuroimmunology. 1999. Vol. 95. Núm. 1-2. Pag. 85-94. 10.1016/S0165-5728(98)00268-9

Rafii-el-Idrissi Benhnia, Mohammed:
Specific binding of Melatonin by purified cell nuclei from spleen and thymus of the rat. En: Journal of Neuroimmunology. 1998. Vol. June 15 (86). Núm. 2. Pag. 190-197. 10.1016/S0165-5728(98)00048-4

Rafii-el-Idrissi Benhnia, Mohammed:
Differential adrenergic regulation of rat pineal cyclic AMP and N-acetyltransferase activity during postnatal development: Involvement of G"s and G"1-2 proteins. En: Journal of Endocrinology. 1997. Vol. 155. Núm. 5. Pag. 305-312. Pmid: 9415065

Rafii-el-Idrissi Benhnia, Mohammed:
Melatonin enhaces IL-2 and IFN-gamma production by human circulating CD4+ cells: A possible receptor-mediated mechanism involving Th1 lymphocytes and monocytes. En: The Journal of Immunology. 1997. Vol. 159. Núm. 2. Pag. 574-581. Pmid: 9218571

Rafii-el-Idrissi Benhnia, Mohammed:
Characterization of binding sites for beta-adrenergic agonists and vasoactive intestinal peptide in the rat harderian gland. En: Microscopy Research and Technique. 1996. Vol. 34. Núm. 2. Pag. 139-143. 8722708

Rafii-el-Idrissi Benhnia, Mohammed:
Binding of [125I]iodocyanopindolol by rat harderian gland crude membranes: kinetic characteristics and day-night variations. En: Bioscience Reports. 1996. Vol. 16. Núm. 5. Pag. 369-377. 8913527

Rafii-el-Idrissi Benhnia, Mohammed:
Specific binding of 2-[125I]iodomelatonin by rat spleen crude membranes: day-night variations and effect of pinealectomy and continuous light exposure. En: Journal of Pineal Research. 1996. Vol. Jan;20. Núm. 1. Pag. 33-38. 10.1111/j.1600-079X.1996.tb00236.x

Rafii-el-Idrissi Benhnia, Mohammed:
Review/Reseña: Immunomodulatory role of melatonin: specific binding sites in human and rodent lymphoid cells. En: Journal of Pineal Research. 1995. Vol. Apr;18. Núm. 3. Pag. 119-126. 10.1111/j.1600-079X.1995.tb00149.x

Rafii-el-Idrissi Benhnia, Mohammed:
Specific binding of 2-[125I]iodomelatonin by rat splenocytes: characterization and its role on regulation of cyclic AMP production. En: Journal of Neuroimmunology. 1995. Vol. Mar;57. Núm. 1-2. Pag. 171-178. 10.1016/0165-5728(94)00182-N

Aportaciones a Congresos

Gómez Navas, Carlos, Silvera , Lucía, Garcia, Raquel, Tejada, Daniel, Rafii-el-Idrissi Benhnia, Mohammed, et. al.:
Psma/Gcpii Expression in B Cells: an Unexpected Mechanism Linking Neurotransmitters Metabolism and Immune Function. Poster en Congreso. III CABIMER International Workshop. Cabimer - Centro Andaluz de Biología Molecular y Medicina Regenerativa. 2024

Bachiller, Sara, Vitallé, Joana, Camprubí Ferrer, Lluís, Gasca, María del Carmen, Ostos Marcos, Francisco José, et. al.:
Analysis of Extracellular Vesicles in Plwh and Their Role in the Immune Activation: Association With HIV Reservoir in the Brain and Neurocognitive Impairment. Comunicación en congreso. XIV Congreso Nacional GeSIDA. A Coruña, España. 2023

Ostos Marcos, Francisco José, Lebrón Romero, José Antonio, Martínez Santa, Marta, Lopez Lopez, Manuel, Vitallé, Joana, et. al.:
Biocompatible Phosphatidylcholine:Cholesterol Liposomes As Immunomodulatory Therapy for Eradicating HIV Reservoirs Ex-Vivo in Plwh. Poster en Congreso. XIV Congreso Nacional GeSIDA. A Coruña, España. 2023

García Bueno, Belén, Ostos Marcos, Francisco José, Martínez Santa, Marta, Vitallé, Joana, Bachiller, Sara, et. al.:
Frequency and Phenotype of Circulating Memory Follicular Cd4 T Helper Cells, and Serum Levels of Soluble Cd27 and Pd1 Are Associated With HIV Disease Progression. Poster en Congreso. XIII Congreso de GESIDA. Sitges, Cataluña, España. 2022

Bachiller, Sara, Vitallé, Joana, Ostos Marcos, Francisco José, Pérez Gómez, A., Camacho Sojo, María Inés, et. al.:
Characterization of Extracellular Vesicles in People Living With HIV and Their Role in the Immune Activation Associated With Neuroinflammation-Induced Neurocognitive Impairment. Poster en Congreso. XIII Congreso de GESIDA. Sitges, Cataluña, España. 2022

Ostos Marcos, Francisco José, Martínez Santa, Marta, Lebrón Romero, José Antonio, Lopez Lopez, Manuel, Moyá Morán, María Luisa, et. al.:
Biocompatible Carriers for Eradicating HIV Reservoirs in Plwh. Comunicación en congreso. XIII Congreso de GESIDA. Sitges, Cataluña, España. 2022

Ostos Marcos, Francisco José, Martínez Santa, Marta, Lebrón Romero, José Antonio, García, Francisco Javier, Bernal Perez, Eva, et. al.:
Biocompatible systems as a promising approach for eradicating HIV reservoirs ex-vivo. Poster en Congreso. FEBS-IUBMB-ENABLE 1st International Molecular Biosciences PhD and Postdoc Conference. Sevilla, España. 2022

Martínez Santa, Marta, Ostos Marcos, Francisco José, Lebrón Romero, José Antonio, López López, Manuel, Bernal Perez, Eva, et. al.:
Enhancement of the potency and efficacy of the antiretroviral drugs in HIV reservoirs through the use of biocompatible liposomes. Poster en Congreso. IX Iberian Meeting on Colloids and Interfaces. Santiago de Compostela, España. 2022

Ostos Marcos, Francisco José, Lebrón Romero, José Antonio, Martínez Santa, Marta, Rafii-el-Idrissi Benhnia, Mohammed, García, Francisco Javier, et. al.:
Biocompatible Metal-Organic Frameworks (MOFs) as vehicles for enhancing the therapeutic effect of antiretroviral drugs in the HIV treatment. Comunicación en congreso. IX Iberian Meeting on Colloids and Interfaces. Santiago de Compostela, España. 2022

Lebrón Romero, José Antonio, Ostos Marcos, Francisco José, Martínez, Marta, Lopez Cornejo, María del Pilar, Rafii-el-Idrissi Benhnia, Mohammed, et. al.:
Metallo-Liposomes derived from [Ru(bpy)3]2+ as nanocarriers of antiretroviral drugs and TLRs in the HIV treatment. Poster en Congreso. International Symposium on Metal Complexes. Valencia. 2022

Pérez Gómez, A., Gasca, María del Carmen, Vitallé, Joana, Ostos Marcos, Francisco José, Trujillo, María, et. al.:
T-CELL RESPONSE QUALITY TO ACUTE SARS-CoV-2 INFECTION, IMMUNE MEMORY, AND HCoV. Poster en Congreso. Conference on Retroviruses and Opportunistic Infections. Online. 2022

Vitallé, Joana, Pérez Gómez, A., Jimenez, Maria Reyes, Gasca, María del Carmen, Bachiller, Sara, et. al.:
IMMUNE PARAMETERS ASSOCIATED WITH LOWER SARS-CoV-2 VACCINATION RESPONSE IN OLD PEOPLE. Poster en Congreso. Conference on Retroviruses and Opportunistic Infections. Online. 2022

Pereira, Rocío, Molina Márquez, Ana, Lopez Lopez, Manuel, Ostos Marcos, Francisco José, Lebrón Romero, José Antonio, et. al.:
Estudio de la capacidad antimicrobiana de nanotubos de carbono frente a patógenos de interés acuícola. Poster en Congreso. III Congreso de Jóvenes Investigadores del Mar. Motril, Granada. 2021

Rosado, Isaac, Pozo Balado, Maria del Mar, De Pablo Bernal, Rebeca, Álvarez Ríos, Ana Isabel, Dominguez, B, et. al.:
Alteraciones inmunovirológicas de pacientes No Repobladores antes del tratamiento antirretroviral. Poster en Congreso. VI Congreso Nacional GESIDA. Grupo de Estudio de Sida-SEIMC y 8ª Reunión Docente de la Red de Investigación en Sida. 2014

De Pablo Bernal, Rebeca, Cañizarez, J, Galve, Mi, Ramos, R, Rosado, Isaac, et. al.:
Los monocitos de pacientes infectados por VIH bajo TARGA supresor presentan mayor activación ex vivo y mayor respuesta a Lps in vitro que sujetos no infectados ancianos. Poster en Congreso. VI Congreso Nacional GESIDA. Grupo de Estudio de Sida-SEIMC y 8ª Reunión Docente de la Red de Investigación en Sida. 2014