Irene García Domínguez
Perfil en ORCID: 0000-0001-6668-1599
Perfil en WOS: J-8352-2018

Grupo de Investigación: Mecanismos de Muerte Celular en Enfermedades Neurodegenerativas
Departamento/Unidad: Bioquímica y Biología Molecular
Situación profesional: Otros

Participa en los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Modulación de la activación microglial asociada a neurodegeneración, relevancia en enfermedades neurodegenerativas (P18-RT-1372 - Equipo Colaborador (Solicitud))
  • Study of the caspase-3 dependent mechanisms governing microglial activation in Parkinson's disease (US-1265062 - Equipo Colaborador (Solicitud))
  
  
• Ayuda a la investigación:
  • Incentivo al Grupo de Investigación CTS-657 (2017/CTS-657 - Investigador)
  
  

Cobertura de la base de datos de proyectos, véase aqui

Publicaciones:

Publicaciones en Revistas

García Revilla, Juan, Ruiz Laza, Rocío, Espinosa Oliva, Ana Maria, Santiago Pavon, Martiniano, García Domínguez, Irene, et. al.:
Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response. En: Cell Death & Disease. 2024. 10.1038/s41419-024-07014-9

Trujillo Cayado, Luis Alfonso, García Domínguez, Irene, Rodriguez Luna, Azahara, Hurtado Fernández, Elena, Santos García, Jenifer:
Cricket Protein as an Innovative Emulsifier for Avocado Oil: Formulation and Characterization of Sustainable Emulsions. En: Applied Sciences. 2024. Vol. 14. Núm. 4. 10.3390/app14041674

Straatoulias, Vassilis, Ruiz Laza, Rocío, Kanatani, Shigeaki, Osman, Ahmed M, Keane, Lily, et. al.:
ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain. En: Frontiers In Cellular Neuroscience. 2023. Vol. 26. Núm. 6

García Domínguez, Irene, Suárez Pereira, Irene, Bravo García, Lidia, Santiago, Martiniano, García Revilla, Juan, et. al.:
The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior. En: Frontiers In Cellular Neuroscience. 2022. Vol. 10. Núm. 839715. 10.3389/fcell.2022.839715

Fernandez Martin, Juan Carlos, Espinosa Oliva, Ana María, Garcia Dominguez, Irene, Rosado Sánchez, Isaac, M. Pacheco, Yolanda, et. al.:
Gal3 Plays a Deleterious Role in aMouseModel of Endotoxemia. En: International Journal of Molecular Sciences. 2022. Vol. 23. Núm. 1170. Pag. 1-25. 10.3390/ijms23031170

Espinosa Oliva, Ana Maria, Garcia Miranda, Pablo, Alonso, Isabel Maria, Carvajal Vazquez, Ana Eloisa, González, Melania, et. al.:
Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon. En: Frontiers in Pharmacology. 2021. Vol. 12. 10.3389/fphar.2021.706439

Bachiller, Sara, Paulus, Agnes, Vazquez, Sandra, García Domínguez, Irene, Deierborg, Tomas:
Maternal separation leads to regional hippocampal microglial activation and alters the behavior in the adolescence in a sex-specific manner. En: Brain, Behavior and Immunity. 2020. Vol. 9. Núm. 100142

García Domínguez, Irene, Suárez Pereira, Irene, Santiago Pavon, Martiniano, Perez Villegas, Eva Maria, Bravo García, Lidia, et. al.:
Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour. En: Progress in Nneuro-Psychopharmacology & Biological Psychiatry. 2020. Vol. 104. 10.1016/j.pnpbp.2020.110030

García Revilla, Juan, Alonso, Isabel Maria, Burguillos García, Miguel Angel, Herrera Carmona, Antonio Jose, Ruiz Laza, Rocío, et. al.:
Review/Reseña: Reformulating pro-oxidant microglia in neurodegeneration. En: Journal of Clinical Medicine. 2019. Vol. 8. Núm. 10. 10.1016/j.celrep.2019.09.013

Carrillo Jimenez, Alejandro, Ruiz Laza, Rocío, García Domínguez, Irene, García Revilla, Juan, Espinosa Oliva, Ana Maria, et. al.:
TET2 Regulates the Neuroinflammatory Response in Microglia. En: Cell Reports. 2019. Vol. 29. Núm. 3. 10.1016/j.celrep.2019.09.013

Tayara, Khadija, Espinosa Oliva, Ana Maria, García Domínguez, Irene, Abdul Ismaiel, Afrah, Boza Serrano, Antonio, et. al.:
Divergent effects of metformin on an inflammatory model of Parkinson's disease. En: Frontiers In Cellular Neuroscience. 2018. Vol. 12. 10.3389/fncel.2018.00440. eCollection 2018

García Domínguez, Irene, García Revilla, Juan, Carrillo Jimenez, Alejandro, Roca, Mª Angustias, Santiago Pavon, Martiniano, et. al.:
Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson`s Disease. En: Frontiers In Cellular Neuroscience. 2018. 10.3389/fncel.2018.00398

Cayero Otero, María Dolores, Espinosa Oliva, Ana Maria, Herrera Carmona, Antonio Jose, García Domínguez, Irene, Fernandez Arevalo, Mercedes, et. al.:
Review/Reseña: Potential Use of Nanomedicine for the Anti-inflammatory Treatment of Neurodegenerative Diseases. En: Current Pharmaceutical Design. 2018. Vol. 24. Núm. 14. Pag. 1589-1616. 10.2174/1381612824666180403113015

Bachiller, Sara, Roca, Mª Angustias, García Domínguez, Irene, Perez Villegas, Eva Maria, Tabares, Lucia, et. al.:
HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System. En: Molecular Neurobiology. 2018. Vol. 55. Núm. 12. Pag. 8856-8868. 10.1007/s12035-018-1021-0

Calderón Montaño, José Manuel, Burgos Moron, Estefania, Orta Vázquez, Manuel Luis, García Domínguez, Irene, López Lázaro, Miguel:
Letters: Bufalin is a steroid receptor coactivator inhibitor-letter. En: Cancer Research. 2015. Vol. 75. Núm. 6. 10.1158/0008-5472.can-14-0398

Calderón Montaño, José Manuel, Burgos Morón, Estefanía, Orta Vázquez, Manuel Luis, Navas, Lola E., García Domínguez, Irene, et. al.:
Review/Reseña: Evaluating the cancer therapeutic potential of cardiac glycosides. En: BioMed Research International. 2014. Vol. 2014. Pag. 9-9. http://dx.doi.org/10.1155/2014/794930

Aportaciones a Congresos

Ruiz Laza, Rocío, García Domínguez, Irene, Roca Ceballos, María Angustias, Perez Villegas, Eva Maria, Sánchez Cabrera, Guillermo, et. al.:
Early activation of microglia in tambalenate mouse model preceding neuronal cerebellar death. Poster en Congreso. 11th FENS Forum Of Neuroscience. Berlin, Alemania. 2018

Tayara, Khadija, García Domínguez, Irene, Espinosa Oliva, Ana Maria, Karim Ismaiel, Afrah, Herrera Carmona, Antonio Jose, et. al.:
Microglial activation decreses with metformin treatment in the in vivo LPS model of Parkinson's disease. Poster en Congreso. 11th FENS Forum Of Neuroscience. Berlin, Alemania. 2018

Felices Navarro, Manuel, García Domínguez, Irene, Espinosa Oliva, Ana Maria, Martinez de Pablos, Rocio, Venero Recio, Jose Luis:
Peripheral inflammation and neuroinflammation in Parkinson disease. Poster en Congreso. Barcelona Young Neuroscientists Symposium. Barcelona (España). 2017

García Revilla, Juan, Boza Serrano, Antonio, Ruiz Laza, Rocío, Carrillo Jimenez, Alejandro, García Domínguez, Irene, et. al.:
Lack of Galectin-3 Protects from Motor Impairment in a Mouse Model of Overexpression of Alpha-Synuclein. Poster en Congreso. 17th SENC. Alicante, España. 2017

García Domínguez, Irene, García Revilla, Juan, Roca Ceballos, Maria Angustias, Carrillo Jimenez, Alejandro, Espinosa Oliva, Ana Maria, et. al.:
Characterization of Caspase 3 Th-IRES-Cre Mice. Poster en Congreso. 17 National Congress of the Spanish Society of Neuroscience. Alicante. 2017

García Domínguez, Irene, Veselá, Karolina, Carrillo Jimenez, Alejandro, García Revilla, Juan, Roca, Maria Angustias, et. al.:
Peripheral Inflammation Exacerbates Neuronal Death in the Mptp Model of Parkinson¿S Disease Through Microglial Activation. Poster en Congreso. XIII European Meeting on Glial Cells in Health and Disease. Edimburgo. Reino Unido. 2017

Orta Vázquez, Manuel Luis, Pastor Carrillo, Nuria María, Domínguez García, Inmaculada, Burgos Morón, Estefanía, Calderón Montaño, José Manuel, et. al.:
Zeburaline induces replication-dependent double-strand breaks which are preferentially repaired by Homologous Recombination. Poster en Congreso. European Environmental Mutagen Society Meeting 2014. Universidad de Lancaster, Reino Unido. 2014