Xavier Bernard Michel Danglemont de Tassigny
Telefono: 955923033
Email: Solicitar correo
Perfil en ORCID: 0000-0002-5346-1156
Perfil en WOS: C-3916-2015
Perfil en Scopus: 24830354600

Grupo de Investigación: Fisiologia Celular y Biofisica
Departamento/Unidad: Fisiología Médica y Biofísica
Situación profesional: Profesor Contratado Doctor

Participa en los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Bioenergética y metabolismo en la Enfermedad de Parkinson (PID2022-136685OA-I00 - Equipo de Investigación)
  • Sensibilidad a Oxígeno y Neurodegeneración (PID2019-106410RB-I00 - Equipo Trabajo (Solicitud))
  • Intolerancia a la hipoxia; efecto sobre la neurogénesis en el cerebro adulto. (US-1261055 - Equipo Colaborador (Solicitud))
  • Molecular mechanisms of acute oxygen sensing (OXYGENSENSING) (2629/0805 - Equipo Trabajo (Solicitud))
  • Sensibilidad al Oxígeno y Neurodegeneración (SAF2012-39343 - Investigador)
  • Convenio de colaboración en materia de apoyo a la transferencia tecnológica en el campo de la biotecnología (CVFB12/005 - Investigador)
  • Sensibilidad al oxígeno y neurodegeneración (CONFMB-001/2006 - Contratado)
  
  

Cobertura de la base de datos de proyectos, véase aqui

Publicaciones:

Publicaciones en Revistas

Enterría Morales, Daniel, Lopez Lopez, Ivette, Lopez Barneo, Jose, D'anglemont de Tassigny, Xavier:
Molecular targets for endogenous glial cell line-derived neurotrophic factor modulation in striatal parvalbumin interneurons. En: Brain Communications. 2020. Vol. 2. Núm. 2. 10.1093/braincomms/fcaa105

Enterría Morales, Daniel, Lopez Lopez, Ivette, Lopez Barneo, Jose, D'anglemont de Tassigny, Xavier:
Role of glial cell line-derived neurotrophic factor in the maintenance of adult mesencephalic catecholaminergic neurons. En: Movement disorders. 2020. 10.1002/mds.27986

Dong, C, Helton, Es, Zhou, P, Ouyang, X, D'anglemont de Tassigny, Xavier, et. al.:
Glial-derived neurotrophic factor is essential for blood-nerve barrier functional recovery in an experimental murine model of traumatic peripheral neuropathy. En: Tissue Barriers. 2018. Vol. 6. Núm. 2. Pag. 1-22. 10.1080/21688370.2018.1479570

D'anglemont de Tassigny, Xavier:
Review/Reseña: Outlook on the neuroprotective effect of estrogen. En: Neural Regeneration Research. 2017. Vol. 12. Núm. 11. Pag. 1799-1800. 10.4103/1673-5374.219036

D'anglemont de Tassigny, Xavier, Jayasena, Channa, Murphy, Kevin G, Dhillo, Waljit S, Colledge, William H:
Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo. En: PLoS One. 2017. Núm. e0176821. 10.1371/journal.pone.0176821

Enterría Morales, Daniel, Lopez Lopez, Ivette, Lopez Barneo, Jose, D'anglemont de Tassigny, Xavier:
Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan-Neuronal Activation in the Female Mouse. En: PLoS One. 2016. Vol. 11. Núm. 10. 10.1371/journal.pone.0164391

D'anglemont de Tassigny, Xavier, Pardal Redondo, Ricardo, Lopez Lopez, Ivette, Lopez Barneo, Jose:
Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival. En: Hypoxia. 2015. Núm. 3. Pag. 15-33. 10.2147/Hp.s78248

D'anglemont de Tassigny, Xavier, Pascual, Alberto, Lopez Barneo, Jose:
GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson's disease. En: Frontiers in Neuroanatomy. 2015. Vol. 9. Núm. 10. 10.3389/fnana.2015.00010. eCollection 2015

Bellefontaine, Charlotte, Chachlaki, Konstantina, Parkhash, Jyoti, Vanacker, Charlotte, Colledge, William H., et. al.:
Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction. En: Journal of Clinical Investigation. 2014. Vol. 128. Núm. 6. Pag. 2550-2559. 10.1172/Jci65928

D'anglemont de Tassigny, Xavier:
Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation. En: The Journal of Neuroscience. 2012. Vol. 32. Núm. 3. Pag. 932-945. 10.1523/Jneurosci.4765-11.2012

D'anglemont de Tassigny, Xavier:
Kisspeptin neurons co-express met-enkephalin and galanin in the rostral periventricular region of the female mouse hypothalamus. En: The Journal of Comparative Neurology. 2011. Vol. 519. Núm. 17. Pag. 3456-3469. 10.1002/cne.22716

D'anglemont de Tassigny, Xavier:
Mll5 is required for normal spermatogenesis. En: PLoS One. 2011. Vol. 6. Núm. 11. 10.1371/journal.pone.0027127

D'anglemont de Tassigny, Xavier:
Frequency-dependent recruitment of fast amino acid and slow neuropeptide neurotransmitter release controls gonadotropin-releasing hormone neuron excitability. En: The Journal of Neuroscience. 2011. Vol. 31. Núm. 7. Pag. 2421-2430. 10.1523/Jneurosci.5759-10.2011

D'anglemont de Tassigny, Xavier:
Review/Reseña: Nitric oxide as key mediator of neuron-to-neuron and endothelia-to-glia communication involved in the neuroendocrine control of reproduction. En: Neuroendocrinology. 2011. Vol. 93. Núm. 2. Pag. 74-89. 10.1159/000324147

D'anglemont de Tassigny, Xavier:
The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent. En: BMC Genomics. 2011. 10.1186/1471-2164-12-209

D'anglemont de Tassigny, Xavier:
Inotropic action of the puberty hormone kisspeptin in rat, mouse and human: cardiovascular distribution and characteristics of the kisspeptin receptor. En: PLoS One. 2011. Vol. 6. Núm. 11. 10.1371/journal.pone.0027601

D'anglemont de Tassigny, Xavier:
Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons. En: Endocrinology. 2010. Vol. 151. Núm. 1. Pag. 312-321. doi: 10.1210/en.2009-0552

D'anglemont de Tassigny, Xavier:
Review/Reseña: Function-related structural plasticity of the GnRH system: a role for neuronal-glial-endothelial interactions. En: Frontiers in Neuroendocrinology. 2010. Vol. 31. Núm. 3. Pag. 241-258. 10.1016/j.yfrne.2010.05.003

D'anglemont de Tassigny, Xavier:
Review/Reseña: Mouse models to study the central regulation of puberty. En: Molecular and Cellular Endocrinology. 2010. Vol. 324. Núm. 1-2. Pag. 12-20. 10.1016/j.mce.2010.01.015

D'anglemont de Tassigny, Xavier:
Role of estradiol in the dynamic control of tanycyte plasticity mediated by vascular endothelial cells in the median eminence. En: Endocrinology. 2010. Vol. 151. Núm. 4. Pag. 1760-1772. 10.1210/en.2009-0870

D'anglemont de Tassigny, Xavier:
Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase depends on estrogens and modulates hypothalamic nitric oxide production during the ovarian cycle. En: Endocrinology. 2010. Vol. 151. Núm. 6. Pag. 2723-2735. 10.1210/en.2010-0007

D'anglemont de Tassigny, Xavier:
Kisspeptin signaling is required for peripheral but not central stimulation of gonadotropin-releasing hormone neurons by NMDA. En: The Journal of Neuroscience. 2010. Vol. 30. Núm. 25. Pag. 8581-8590. 10.1523/Jneurosci.5486-09.2010

D'anglemont de Tassigny, Xavier:
Review/Reseña: The role of kisspeptin signaling in reproduction. En: Physiology. 2010. Vol. 25. Núm. 4. Pag. 207-217. 10.1152/physiol.00009.2010

D'anglemont de Tassigny, Xavier:
Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures. En: Journal of Neurochemistry. 2009. Vol. 109. Núm. 1. Pag. 214-224. 10.1111/j.1471-4159.2009.05949.x

D'anglemont de Tassigny, Xavier:
Distribution of kisspeptin neurones in the adult female mouse brain. En: Journal of Neuroendocrinology. 2009. Vol. 21. Núm. 8. Pag. 673-682. 10.1111/j.1365-2826.2009.01892.x

D'anglemont de Tassigny, Xavier:
Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. En: The Journal of Neuroscience. 2008. Vol. 28. Núm. 35. Pag. 8691-8697. 10.1523/Jneurosci.1775-08.2008

D'anglemont de Tassigny, Xavier:
Review/Reseña: The role of kisspeptin signalling in the regulation of the GnRH-gonadotrophin ovarian axis in mice. En: Annales d'Endocrinologie. 2008. Vol. 71. Núm. 3. Pag. 198-200. 10.1016/j.ando.2010.02.011

D'anglemont de Tassigny, Xavier:
Coupling of neuronal nitric oxide synthase to NMDA receptors via postsynaptic density-95 depends on estrogen and contributes to the central control of adult female reproduction. En: The Journal of Neuroscience. 2007. Vol. 27. Núm. 23. Pag. 6103-6114

D'anglemont de Tassigny, Xavier:
Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. En: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2007. Vol. 104. Núm. 25. Pag. 10714-10719

D'anglemont de Tassigny, Xavier:
Role of glial cell line-derived neurotrophic factor in the maintenance of adult mesencephalic catecholaminergic neurons

Aportaciones a Congresos

D'anglemont de Tassigny, Xavier:
Pharmacological stimulation of endogenous GDNF in the striatum: towards a future neuroprotective therapy in Parkinson¿s disease?. Sesión no plenaria en Congreso. VI International Congress on Research and Innovation in Neurodegenerative Diseases. XII CIBERNED Scientific Forum. - Santiago de Compostela (A Coruña), España. 2018

D'anglemont de Tassigny, Xavier:
Towards a specific stimulation of endogenous GDNF production by striatal parvalbumin interneurons. Comunicación en congreso. International Conference on Neurotrophic Factors 2018. - Salamanca, España. 2018

Enterría Morales, Daniel, Lopez Lopez, Ivette, Lopez Barneo, Jose, D'anglemont de Tassigny, Xavier:
Molecular insights into the endogenous GDNF expression of striatal parvalbumin neurons: a possible tool for neuroprotective therapy for Parkinson¿s disease?. Poster en Congreso. SfN Annual Meeting. Washington DC (EEUU). 2017

D'anglemont de Tassigny, Xavier, Enterría Morales, Daniel, Lopez Lopez, Ivette, Lopez Barneo, Jose:
Stimulation of endogenous striatal GDNF: a neuroprotective therapy for Parkinson¿s disease?. Poster en Congreso. NeuroFrance. Burdeos (Francia). 2017

D'anglemont de Tassigny, Xavier, Enterría Morales, Daniel, Lopez Lopez, Ivette, Lopez Barneo, Jose:
Transcriptomic changes in parvalbumin positive interneurons expressing Cre recombinase. Poster en Congreso. SfN Annual Meeting. Washington DC (EEUU). 2017

Patentes:

Lopez Barneo, Jose, D'anglemont de Tassigny, Xavier, Enterría Morales, Daniel, Lopez Lopez, Ivette:
Composiciones capaces de modular la estimulación de GDNF endógeno para el tratamiento de enfermedades neurodegenerativas. Otra modalidad de propiedad industrial. Solicitud: 2017-08-29

Tesis dirigidas y co-dirigidas:

(Doctorando no grabado)
Estimulación del GDNF endógeno en el estriado de ratón. Tesis Doctoral. 2019