Elena Gavilán Dorronzoro
Telefono: 954556756
Perfil en ORCID: 0000-0002-8173-2638
Perfil en WOS: C-2230-2017
Perfil en Scopus: 36672906400

Grupo de Investigación: Envejecimiento y Neurodegeneración
Departamento/Unidad: Bioquímica y Biología Molecular
Situación profesional: Otros

Participa en los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Efecto de la neuroinflamacion sobre la activación de las vías UPR, ERAD Y Akt/GSK3/b-catenina en respuesta al bloqueo del proteosoma. Relación con la neurodegeneración hipocampal (PI12/00445 - Investigador)
  • Papel de la autofagia en procesos neurodegenerativos inducidos por disfunción del proteasoma o daño isquémico: implicación del envejecimiento y la inflamación (PS09/00848 - Becario)
  
  
• Ayuda a la investigación:
  • Incentivo al Grupo de Investigación CTS-257 (2017/CTS-257 - Investigador)
  • Incentivo al Grupo de Investigación CTS-257 (2010/CTS-257 - Contratado)
  
  

Cobertura de la base de datos de proyectos, véase aqui

Publicaciones:

Publicaciones en Revistas

Gabasa, Marta, Radisky, Evette S, Ikemori, Rafael, Bertolini, Giulia, Arshakyan, Marselina, et. al.:
MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence. En: Cancer Letters. 2021. Vol. 507. Núm. 1. Pag. 1-12. 10.1016/j.canlet.2021.01.028

Montagut, Clara, Cañadas, Israel, Gavilán Dorronzoro, Elena, Arpi, Oriol, Bellosillo, Beatriz, et. al.:
Meeting-Abstract: Sym004 to circumvent resistance to cetuximab driven by emergence of EGFR extracellular mutations in colorectal cancer. En: Journal of Clinical Oncology. 2015. Vol. 33. Núm. 15. http://ascopubs.org/doi/abs/10.1200/jco.2015.33.15_suppl.e13600

Martinez, Alejandro, Hernandez, Anna, Arpi, Oriol, Menendez, Silvia, Iarchouk, Natalia, et. al.:
Meeting-Abstract: Targeting the PI3K/AKT/mTOR pathway with MLN0128 (mTORC1/2 inh) and MLN1117 (PI3K alpha inh) in bladder cancer: Rational for its testing in clinical trials. En: Journal of Clinical Oncology. 2015. Vol. 33. Núm. 7. https://doi.org/10.1200/jco.2015.33.7_suppl.369

Lazzari, Luca, Arena, Sabrina, Bellosillo, Beatriz, Siravegna, Giulia, Martínez, Alejandro, et. al.:
Meeting-Abstract: Proceedings: AACR 106th Annual Meeting 2015; Abstract 3588: Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer. En: Cancer Research. 2015. Vol. 75. Núm. 15. https://doi.org/10.1158/1538-7445.AM2015-3588

Chaalal, Makhlouf, Gavilán Dorronzoro, Elena, Louaileche, Hayette, Ruano, Diego, Parrado Rubio, Juan, et. al.:
Anti-inflammatory activity of phenolic extracts from different parts of prickly pear on lipopolysaccharide-stimulated N13 microglial cells. En: International Journal of Phytomedicine. 2015. Vol. 7. Núm. 4. Pag. 411-419

Arena, Sabrina, Bellosillo, Beatriz, Siravegna, Giulia, Martínez, Alejandro, Cañadas, Israel, et. al.:
Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer. En: Clinical Cancer Research. 2015. Vol. 21. Núm. 9. Pag. 2157-66. 10.1158/1078-0432.ccr-14-2821

Daza Navarro, Paula, Gavilán Dorronzoro, Elena, Giraldez Macias, Servando, Sanchez Aguayo, Inmaculada, Romero Portillo, Francisco, et. al.:
Meeting-Abstract: Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3ß dependent mechanism. En: The FEBS Journal. 2015. Vol. 282. Núm. Supplement 1. Pag. 159-159

Gavilán Dorronzoro, Elena, Giraldez Macias, Servando, Sanchez Aguayo, Inmaculada, Romero Portillo, Francisco, Ruano, Diego, et. al.:
Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3ß dependent mechanism. En: Scientific Reports. 2015. Vol. 5. Núm. 10027. Pag. 1-13. doi: 10.1038/srep10027

Gavilán Dorronzoro, Elena, Pintado Losa, Cristina, Gavilán Dorronzoro, María de la Paz, Daza Navarro, Paula, Sanchez Aguayo, Inmaculada, et. al.:
Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress. En: Neurobiology of Aging. 2015. Vol. 36. Núm. 5. Pag. 1953-1963. 10.1016/j.neurobiolaging.2015.02.025

Enriquez Barreto, Lilian, Cuesto, German, Domínguez Iturza, Nuria, Gavilán Dorronzoro, Elena, Ruano, Diego, et. al.:
Learning improvement after PI3K activation correlates with de novo formation of functional small spines. En: Frontiers in Molecular Neuroscience. 2014. Vol. 6. Núm. 54. Pag. 1-17. 10.3389/fnmol.2013.00054

Gavilán Dorronzoro, Elena, Sanchez Aguayo, Inmaculada, Daza Navarro, Paula, Ruano, Diego:
GSK-3b signaling determines autophagy activation in the breast tumorcell line MCF7 and inclusion formation in the non-tumor cell line MCF10A in response to proteasome inhibition. En: Cell Death & Disease. 2013. Vol. 4. Núm. e572. Pag. 1-11. 10.1038/cddis.2013.95

Gavilán Dorronzoro, María de la Paz, Pintado Losa, Cristina, Gavilán Dorronzoro, Elena, García Cuervo, María Luisa, Castaño Navarro, Angelica, et. al.:
Age-related differences in the dynamics of hippocampal proteasome recovery. En: Journal of Neurochemistry. 2012. Vol. 123. Núm. 4. Pag. 635-644. 10.1111/j.1471-4159.2012.07932.x

Gavilán Dorronzoro, María de la Paz, Pintado Losa, Cristina, Gavilán Dorronzoro, Elena, García Cuervo, Luisa M., Gutiérrez Pérez, Antonia, et. al.:
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus. En: Journal of Neuroinflammation. 2012. Vol. 9. Núm. 1. Pag. 87-96. 10.1186/1742-2094-9-87

Dasuri, Kalavathi, Ebenezer, Philip J., Uranga, Romina M., Gavilán Dorronzoro, Elena, Zhang, Le, et. al.:
Amino Acid Analog Toxicity in Primary Rat Neuronal and Astrocyte Cultures: Implications for Protein Misfolding and Tdp-43 Regulation. En: Journal of Neuroscience Research. 2011. Vol. 89. Núm. 9. Pag. 1471-1477

Dasuri, Kalavathi, Ebenezer, Philip J., Zhang, Le, Fernandez Kim, Sun Ok, Uranga, Romina M., et. al.:
Selective Vulnerability of Neurons to Acute Toxicity After Proteasome Inhibitor Treatment: Implications for Oxidative Stress and Insolubility of Newly Synthesized Proteins. En: Free Radical Biology & Medicine. 2010. Vol. 49. Núm. 8. Pag. 1290-1297

Ebenezer, Philip J., Weidner, Adam M., Levine, Harry, Markesbery, William R, Murphy, M. Paul, et. al.:
Neuron Specific Toxicity of Oligomeric Amyloid-ß: Role for Jun-Kinase and Oxidative Stress. En: Journal of Alzheimers Disease. 2010. Vol. 22. Núm. 3. Pag. 839-848

Gavilán Dorronzoro, María de la Paz, Pintado Losa, Cristina, Gavilán Dorronzoro, Elena, Jimenez Muñoz, Sebastian, Rios Sanchez, Rosa Maria, et. al.:
Dysfunction of the Unfolded Protein Response Increases Neurodegeneration in Aged Rat Hippocampus Following Proteasome Inhibition. En: Aging Cell. 2009. Vol. 8. Pag. 654-665

Aportaciones a Congresos

Gavilán Dorronzoro, Elena, Roca, Jesús, Rios Sanchez, Rosa Maria:
Contribution of Centrosome- and Golgi Apparatus-Microtubule Nucleation to Epithelial Polarization. Poster en Congreso. 1st Joint Congress of the Spanish Societies for Cell Biology, genetics and Developmental Biology. Asturias (Gijón). 2017

Ruano, Diego, Gavilán Dorronzoro, María de la Paz, Pintado Losa, Cristina, Gavilán Dorronzoro, Elena, Castaño Navarro, Angelica:
Neuroinflammation, autophagy and proteasome. Sesión plenaria en Congreso. 6th Conference of the Mediterranean Neuroscience Society. La Valetta (Malta). 2017

Gavilán Dorronzoro, Elena:
Mejora terapéutica de la modulación autofágica en cáncer / Therapeutic advantage of autophagy modulation in cancer. Ponencia en Congreso. 11º Simposio Internacional de Oncología Traslacional. Casa de Convalescència ¿ Fundació UAB, Barcelona. 2015

Gavilán Dorronzoro, Elena, Giraldez Macias, Servando, Sanchez Aguayo, Inmaculada, Romero Portillo, Francisco, Martín Rubio, María Esther, et. al.:
A GSK-3ß dependent mechanism is the responsible for the escape of the breast cancer cell line MCF7 from G1/S arrest induced by proteasome inhibition. Poster en Congreso. XVI congreso de la Sociedad Española de Biología Celular. Seville, Spain. 2015

Daza Navarro, Paula, Gavilán Dorronzoro, Elena, Giraldez Macias, Servando, Sanchez Aguayo, Inmaculada, Romero Portillo, Francisco, et. al.:
Breast cancer cell line MCF7 escapes from G1/ S arrest induced by proteasome inhibition through a GSK-3ß dependent mechanism. Poster en Congreso. 40th FEBS Congress. Berlin, GERMANY. 2015

Gavilán Dorronzoro, Elena, Pintado Losa, Cristina, Gavilán Dorronzoro, María de la Paz, Daza Navarro, Paula, Sanchez Aguayo, Inmaculada, et. al.:
Defective cross-talk between the ubiquitin proteasome system and the autophagy lysosomal pathway under proteasome stress in aged rat hippocampus. Poster en Congreso. 40th FEBS Congress. The Biochemical Basis of Life. Berlin, Alemania. 2015

Gavilán Dorronzoro, Elena, Pintado Losa, Cristina, Gavilán Dorronzoro, María de la Paz, Daza Navarro, Paula, Sanchez Aguayo, Inmaculada, et. al.:
Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress. Role of GSK-3¿ as master regulator. Comunicación en congreso. XVI Congress SEBC. 2015

Gavilán Dorronzoro, Elena, Daza Navarro, Paula, Sanchez Aguayo, Inmaculada, Castaño Navarro, Angelica, Ruano, Diego:
Defective cross-talk between the UPS and the ALP in aged rats subjected to proteasome stress: role of GSK-3beta as master regulator. Comunicación en congreso. Joint Meeting of Nordic, Spanish and French Autophagy Networks. Toulouse, France. 2014

Gavilán Dorronzoro, Elena, Daza Navarro, Paula, Sanchez Aguayo, Inmaculada, Ruano, Diego:
Phosphorylated GSK3 increases in tumoral MCF7 cells following proteasome inhibition; involvement in autophagy-mediated cell death. Poster en Congreso. XIV Congreso de la SEBC. 2011

Pintado Losa, Cristina, Gavilán Dorronzoro, María de la Paz, Gavilán Dorronzoro, Elena, Gutierrez, Antonia, Vitorica Ferrandez, Francisco Javier, et. al.:
La Neuroinflamación y la Disfunción del Proteosoma Actúan Como Factores Sinérgicos Favoreciendo la Agregación de Proteínas en el Hipocampo de la Rata Vieja. Poster en Congreso. XIV Congreso Nacional de la Sociedad Española de Neurociencia. Salamanca. 2011. Actas del XIV Congreso Nacional de la Sociedad Española de Neurociencia. 21. 21

Ruano, Diego, Gavilán Dorronzoro, María de la Paz, Pintado Losa, Cristina, Gavilán Dorronzoro, Elena, Vitorica Ferrandez, Francisco Javier, et. al.:
Qualitative and Quantitative Age-Related Differences in the Proteasome Biogenesis Induced by Protein Accumulation: Role of Neuroinflammation. Poster en Congreso. 7th Fens Forum of European Neuroscience. Amsterdam. 2010. Fens Forum Abstracts, Volume 5, 2010. 078.85. 078.85