Responsable: Martiniano Santiago Pavón
Tipo de Proyecto/Ayuda: Plan Nacional del 2007
Referencia: SAF2007-62425
Fecha de Inicio: 01-10-2007
Fecha de Finalización: 04-10-2011

Empresa/Organismo financiador/es:

• Ministerio de Educación y Ciencia

Equipo:

• Investigadores:
  • Rocío Martínez de Pablos
• Becarios:
  • María José Delgado Cortés

Contratados:

• Investigadores:
  • Ruth Fernández Villaran
• Técnicos/Personal Administrativo:
  • Sandro Ramón Argüelles Castilla

Resumen del proyecto:

Relación de publicaciones realizadas con este proyecto:

1. M. Santiago, M.C. Hernández-Romero, A. Machado and J. Cano. Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP⁺ does not. European Journal of Pharmacology 609 (2009) 58-64.

2. R.F. Villarán, R.M. de Pablos, S. Argüelles, A.M. Espinosa-Oliva, M. Tomás-Camardiel, A.J. Herrera, J. Cano and A. Machado. The intranigral injection of tissue plasminogen activator induced blood-brain barrier disruption, inflammatory process and degeneration of the dopaminergic system of the rat. Neurotoxicology 30 (2009) 403-413.

3. J.L. Venero, R. Mauriño, A. Machado and M. Santiago. Striatal ablation of GABAergic neurons prevents the in vivo neuroprotective effect of DCG-IV against the MPP⁺-induced neurotoxicity on dopaminergic nerve terminals. Neurochemistry International 57 (2010) 979-984.

4. R. Mauriño, A. Machado and M. Santiago. Efect of in vivo striatal perfusion of lipopolysaccharide on dopamine metabolites. Neuroscience Letters 475 (2010) 121-123.

5. S. Argüelles, A.J. Herrera, E. Carreño-Müller, R.M. de Pablos, R.F. Villarán, A.M. espinosa-Oliva, A. Machado and J. Cano. Degeneration of dopaminergic neurons induced by thrombin injection in the substantia nigra of the rat is enhanced by dexamethasone: role of monomaine oxidase enzyme. Neurotoxicology 31 (2010) 55-66.

6. A.M. Espinos-Oliva, R.M. de Pablos, R.F. Villarán, S. Argüelles, J.L. Venero, A. Machado and J. Cano. Stress is critical for LPS-indiced activation of microglia and damage in the rat hippocampus. Neurobiology of Aging 32 (2011) 85-102.