» Investigación » SISIUS - Investigación en la USE

Manuel Pernia Leal
Telefono: 954556738
Email: Solicitar correo
Perfil en ORCID: 0000-0001-8160-0574
Perfil en Scopus: 56519272300

Grupo de Investigación: Estereoquimica y Sintesis Asimetrica
Departamento/Unidad: Química Orgánica y Farmacéutica
Situación profesional: Profesor Titular de Universidad

Responsable de los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Desarrollo de nanosistemas multifuncionales basados en metalo-profármacos combinados con nanopartículas magnéticas para aplicaciones teranósticas (PID2020-118448RB-C22)
  • Diseño y Síntesis de Nanomateriales Híbridos a partir de Complejos de Ru con potencial actividad anticancerosa (P18-RT-1663)
  
  
• Ayuda a la investigación:
  • Ayudas para el uso de los Servicios Generales de Investigación (PPI526/2020)
  • Multi-functional hybrid nano-heterostructures for in vivo imaging and cancer therapy. (PP2018-11360)
  
  

Participa en los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Nuevas estrategias para la optimización de la transferencia de quiralidad en procesos de interés sintético y terapéutico: Aproximaciones modulares para la síntesis de bissulfinilderivados enantiopuros (US-1381590 - Equipo de Investigación)
  • Sistemas nanoestructurados direccionados por el péptido intesinal vasoactivo (VIP) como alternativas para la detección y tratamiento de cáncer de próstata: caracterización preclínica (PI14/01600 - Equipo de Investigación)
  • Diseño y Síntesis de Nuevos Sistemas Moleculares y Supramoleculares Nanométricos como Herramientas Útiles en Síntesis Asimétrica y Biomedicina (CTQ2013-49066-C2-2-R - Equipo de Investigación (Alta/Baja))
  • Nuevos antagonistas de los receptores NK-1: diseño, síntesis y aplicación en el tratamiento contra el cáncer (P06-FQM-01852 - Otro Investigador)
  
  
• Ayuda a la investigación:
  • Incentivo al Grupo de Investigación FQM-102 (2017/FQM-102 - Investigador)
  
  

Cobertura de la base de datos de proyectos, véase aqui

Publicaciones:

Publicaciones en Revistas

Recio Jiménez, Rocio, Lerena, Patricia, Pozo, Esther, Calderón Montaño, José Manuel, Burgos Morón, Estefanía, et. al.:
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity. En: Journal of Medicinal Chemistry. 2021. Vol. 64. Núm. 14. Pag. 10350-10370. 10.1021/acs.jmedchem.1c00793

Caro Salazar, Carlos, Páez, Jose María, Beltrán Custodio, Ana María, Pernia Leal, Manuel, García Martín, María Luisa:
PEGylated Terbium-Based Nanorods as Multimodal Bioimaging Contrast Agents. En: ACS Applied Nano Materials. 2021. Vol. 4. Núm. 4. Pag. 4199-4207. 10.1021/acsanm.1c00569

Caro Salazar, Carlos, Gámez Márquez, Francisco, Quaresma, Pedro, Páez, Jose María, Dominguez, Alejandro, et. al.:
Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapy. En: Pharmaceutics. 2021. Vol. 13. Pag. 416,1-416,22. doi.org/10.3390/pharmaceutics13030416

Caro Salazar, Carlos, Quaresma, Pedro, Pereira, Eulalia, Pernia Leal, Manuel, García Martín, María Luisa, et. al.:
Synthesis and Characterization of Elongated-Shaped Silver Nanoparticles as a Biocompatible Anisotropic SERS Probe for Intracellular Imaging: Theoretical Modeling and Experimental Verification. En: Nanomaterials. 2019. Vol. 9. Núm. 2. 10.3390/nano9020256

Caro Salazar, Carlos, Pernia Leal, Manuel, García Martín, María Luisa:
In Vivo Pharmacokinetics of Magnetic Nanoparticles. En: Methods in Molecular Biology. 2018. Vol. 1718. Pag. 409-419. 10.1007/978-1-4939-7531-0_24

Materia, Maria Elena, Pernia Leal, Manuel, Scotto, Marco, Balakrishnan, Preethi Bala, Avugadda, Sahitya Kumar, et. al.:
Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools. En: Bioconjugate Chemistry. 2017. Vol. 28. Núm. 11. Pag. 2707-2714. 10.1021/acs.bioconjchem.7b00432

Pernia Leal, Manuel, Caro Salazar, Carlos, García Martín, María Luisa:
Shedding Light on Zwitterionic Magnetic Nanoparticles: Limitations for in vivo Applications. En: Nanoscale. 2017. Vol. 9. Pag. 8176-8184. 10.1039/C7nr01607g

Caro Salazar, Carlos, García Martín, María Luisa, Pernia Leal, Manuel:
Manganese-Based Nanogels as pH Switches for Magnetic Resonance Imaging. En: Biomacromolecules. 2017. Vol. 18. Núm. 5. Pag. 1617-1623. 10.1021/acs.biomac.7b00224

Caro Salazar, Carlos, Dalmases, Mariona, Figuerol, Albert, García Martín, María Luisa, Pernia Leal, Manuel:
Highly water-stable rare ternary Ag¿Au¿Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents. En: Nanoscale. 2017. Vol. 9. Núm. 21. Pag. 7242-7251. 10.1039/c7nr01110e

Khiar el Wahabi, Noureddine, Assali, Mohyeddin, Pernia Leal, Manuel, Cid Martín, Juan José, Valdivia Giménez, Victoria Esther, et. al.:
Meeting-Abstract: Carbon-based glyco-nanomaterials : a smart tool for the selective aggregation of bacteria and advanced drug delivery. En: Abstracts, 28th International Carbohydrate Symposium, ACS. 2016. Vol. 2016

Pernia Leal, Manuel, Muñoz Hernandez, Maria del Carmen, Berry, Catherine C., García Martín, María Luisa:
In vivo pharmacokinetics of T2 contrast agents based on iron oxide nanoparticles: optimization of blood circulation times. En: RSC Advances. 2015. Vol. 5. Núm. 94. Pag. 76883-76891. 10.1039/C5ra15680g

Pernia Leal, Manuel:
Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)Responsive Coating and Their Application in Hyperthermia and Heat-Triggered Drug Delivery. En: ACS Applied Materials and Interfaces. 2015

Pernia Leal, Manuel:
Instructable Nanoparticles Using Dynamic Combinatorial Chemistry. En: Langmuir. 2015

Fernandez, Td, Pernia Leal, Manuel, Torres Jaen, Maria Jose, Mayorga Mayorga, Cristobalina:
Intracellular accumulation and immunological properties of fluorescent gold nanoclusters in human dendritic cells. En: Biomaterials. 2015

Pernia Leal, Manuel:
Mesoscale Assemblies of Iron Oxide Nanocubes as Heat Mediators and Image Contrast Agents. En: Langmuir. 2015

Pernia Leal, Manuel, Rivera Fernandez, Sara, Muñoz Franco, Jaime, Pozo Pérez, David, De la Fuente, Jesús, et. al.:
Long-circulating PEGylated manganese ferrite nanoparticles for MRI-based molecular imaging. En: Nanoscale. 2015. Vol. 7. Núm. 5. Pag. 2050-2059. 10.1039/c4nr05781c

Pernia Leal, Manuel, Assali, M., Cid, J.j., Valdivia Giménez, Victoria Esther, Franco, J.m., et. al.:
Synthesis of 1D-Glyconanomaterials by a Hybrid Noncovalent-Covalent Functionalization of Single Wall Carbon Nanotubes: a Study of their Selective Interactions with Lectins and with Live Cells. En: Nanoscale. 2015. Núm. 7. Pag. 19259-19272

Pernia Leal, Manuel:
Ligand effect on the size, valence state and red/ near infrared photoluminescence of bidentate thiol gold nanoclusters. En: Nanoscale. 2014

Alcantara, David, Pernia Leal, Manuel, García Bocanegra, Irene, García Martín, María Luisa:
Review/Reseña: Molecular imaging of breast cancer: present and future directions. 2014. Vol. 2

Pernia Leal, Manuel:
Atomic Ligand Passivation of Colloidal Nanocrystal Films via their Reaction with Propyltrichlorosilane. En: Chemistry of Materials. 2013

Pernia Leal, Manuel:
Synthesis and non-covalent functionalization of carbon nanotubes rings: new nanomaterials with lectin affinity. En: Nanotechnology. 2013

Pernia Leal, Manuel:
Glyconanosomes: Disk-Shaped Nanomaterials for the Water Solubilization and Delivery of Hydrophobic Molecules. En: ACS Nano. 2013

Pernia Leal, Manuel:
Controlled Release of Doxorubicin Loaded within Magnetic Thermoresponsive Nanocarriers under Magnetic and Thermal Actuation in a Microfluidic Channel. En: ACS Nano. 2012

Khiar el Wahabi, Noureddine, Pernia Leal, Manuel, Navas García, Raquel, Moya López, Juan Francisco, García Pérez, Maria Victoria:
P/S ligands derived from carbohydrates in Rh-catalyzed hydrosilylation of ketones. En: Organic and Biomolecular Chemistry. 2012. Vol. 10. Núm. 2. Pag. 355-360

Pernia Leal, Manuel:
Magnetic Nanocarriers with Tunable pH Dependence for Controlled Loading and Release of Cationic and Anionic Payloads. En: Advanced Materials. 2011

Pernia Leal, Manuel:
Copper-Catalyzed Azide¿Alkyne Cycloaddition in the Synthesis of Polydiacetylene: ¿Click Glycoliposome¿ as Biosensors for the Specific Detection of Lectins. En: Chemistry: A European Journal. 2011

Pernia Leal, Manuel:
¿Nanohybrids¿ Based on pH-Responsive Hydrogels and Inorganic Nanoparticles for Drug Delivery and Sensor Applications. En: Nano Letters. 2011

Pernia Leal, Manuel:
Improved Non-Covalent Biofunctionalization of Multi-Walled Carbon Nanotubes Using Carbohydrate Amphiphiles with a Butterfly-Like Polyaromatic Tail. En: Nano Research. 2010

Pernia Leal, Manuel:
Non-covalent functionalization of carbon nanotubes with glycolipids: glyconanomaterials with specific lectin-affinity. 2009

Khiar el Wahabi, Noureddine, Pernia Leal, Manuel, Baati, Rachid, Mioskowsky, Charles, Fernandez Fernandez, Inmaculada:
Tailoring Carbon Nanotubes Surfaces With Glyconanorings: New Bionanomaterials With Specific Lectin Affinity. En: Chemical Communications. 2009. Pag. 4121-4123

Pernia Leal, Manuel:
C2-Symmetric Bissulfoxides as Organocatalysts in the Allylation of Benzoyl Hydrazones: Spacer and Concentration Effects. En: Organic Letters. 2007

Otra participación en Libros de Actas

Khiar el Wahabi, Noureddine (Editor/a), Assali, M. (Coeditor/a), Pernia Leal, Manuel (Codirector), Cid Martín, J. (Coeditor/a), Valdivia Giménez, Victoria Esther (Coeditor/a), et. al.:
Carbon-Based Glyco-Nanomaterials: a Smart Tool for the Selective Aggregation of Bacteria and Advanced Drug Delivery. 2016

Aportaciones a Congresos

Estruch Blasco, Manel, Calderón Montaño, José Manuel, López Lázaro, Miguel, Pernia Leal, Manuel:
New Ruthenium Pro-Drugs Containing Hybrid Nanomaterials. Poster en Congreso. XXXIX Reunión Bienal de la Sociedad Española de Química,. - Zaragoza, España. 2023

Pernia Leal, Manuel, Caro Salazar, Carlos, García Martín, María Luisa:
Tailoring the outermost surfaces of magnetic nanoparticles for in vivo applications. Ponencia en Congreso. Applied Nanotechnology and Nanoscience International Conference 2018. Berlin, - Berlin, alemania. 2018

Caro Salazar, Carlos, García Martín, María Luisa, Pernia Leal, Manuel:
Metal ternary Ag-Au-Se chalcogenide nanoparticles as novel X-ray computed tomography contrast agents. Ponencia en Congreso. Applied Nanotechnology and Nanoscience International Conference 2018. Berlin, - Berlin, alemania. 2018

Pernia Leal, Manuel, Caro Salazar, Carlos, Muñoz Hernandez, Maria del Carmen, García Martín, María Luisa:
Nanopartículas Magnéticas para Imagen Molecular por MRI (MMRI). Ponencia en Congreso. ESMRMB 2017, 34th Annual Scientific Meeting. Barcelona, España. 2017

Caro Salazar, Carlos, García Martín, María Luisa, Pernia Leal, Manuel:
Manganese-Based Nanogels as pH Switches for Magnetic Resonance Imaging. Poster en Congreso. ESMRMB 2017, 34th Annual Scientific Meeting. Barcelona, España. 2017

Pernia Leal, Manuel, García Martín, María Luisa:
Effect of PEG molecular weight of superparamagnetic iron oxide nanoparticles (SPIONs) on the in vivo biodistribution by Magnetic Resonance Imaging. Ponencia en Congreso. NanoPT 2016. Braga (Portugal). 2016

García Martín, María Luisa, Muñoz Hernandez, Maria del Carmen, Pernia Leal, Manuel:
Effect of PEG molecular weight of superparamagnetic iron oxide nanoparticles (SPIONs) on the in vivo biodistribution by Magnetic Resonance Imaging. Poster en Congreso. ESMRMB 2015, 32nd Annual Scientific Meeting. Edimburgo, Reino Unido. 2015

Pernia Leal, Manuel:
Long-circulating PEGylated Magnetic Nanoparticles for MRI-based molecular imaging. Ponencia en Congreso. Long-circulating PEGylated Magnetic Nanoparticles for MRI-based molecular imaging. Sitges. 2015

Pernia Leal, Manuel:
¿Tracking the controlled release of Doxorubicin from magnetic thermo-responsive polymer nanobeads in a microfluid channel on a chip. Ponencia en Congreso. ¿Tracking the controlled release of Doxorubicin from magnetic thermo-responsive polymer nanobeads in a microfluid channel on a chip¿. San Sebastián. 2012

Pernia Leal, Manuel:
Tracking the controlled release of Doxorubicin from magnetic thermo-responsive polymer nanobeads in a microfluid channel on a chip¿. Ponencia en Congreso. Tracking the controlled release of Doxorubicin from superparamagnetic thermo-responsive polymer nanobeads in a microfluid channel on a chip. Thesaloniki (Grecia) 2012. 2012

Khiar el Wahabi, Noureddine, Assali, M., Pernia Leal, Manuel, Fernandez Fernandez, Inmaculada, Baati, R., et. al.:
Supramolecular Self-Organization of Neoglycolipids on Carbon Nanotubes: New Bioactive Glyconanosystems. Poster en Congreso. 17th European Symposium on Organic Chemistry (ESOC 2011). Creta (Grecia). 2011

Fernandez Fernandez, Inmaculada, Navas García, Raquel, Suárez, B., Pernia Leal, Manuel, Khiar el Wahabi, Noureddine:
Organizing the Chiral Information encoded by Carbohydrates: Application in Asymmetric Catalysis. Poster en Congreso. : Challenges in Organic Chemistry and Chemical Biology (ISACS1). California, San Francisco; Estados Unidos de America. 2009

Patentes:

Khiar el Wahabi, Noureddine, Pernia Leal, Manuel, Fernandez Fernandez, Inmaculada:
Neoglycolipids, used to prepare supramolecular aggregates with carbon nanotubes for medical or diagnostic applications. Patente de invención, Propiedad industrial. Solicitud: 2009-01-07