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Ficha personal - Leonardo Gómez Sánchez


Leonardo Gómez Sánchez
Email: Solicitar correo

Departamento/Unidad: Fisiología Médica y Biofísica
Situación profesional: Personal Investigador en Formación (MEC)

Participa en los siguientes proyectos/ayudas en la US:

  • Proyecto de investigación:
    • Análisis Genético y Funcional de Co-Chaperones Sinápticos en el Mantenimiento y la Degeneración Sináptica (P12-CTS-2232 - Investigador)
    • Función Molecular de Cysteine String Protein-Alpha (CSP-Alpha) en Sinapsis Gabaérgicas en Neuronas Hipocampales de Ratón en Cultivo, in Situ e in Vivo y en Neuronas Humanas en Cultivo (BFU2010-15713 - Investigador)
    • Manipulation of synapses with nanotechnologies to study molecular mechanisms of neurodegeneration (EUI2009-04084 - Contratado)

  • Ayuda a la investigación:
    • Incentivo al Grupo de Investigación CTS-600 (2017/CTS-600 - Investigador)
    • Incentivo al Grupo de Investigación CTS-600 (2011/CTS-600 - Investigador)
    • Incentivo al Grupo de Investigación CTS-600 (2010/CTS-600 - Investigador)
    • Estudio de validación del uso de micro-arrays basados en sensores impedimétricos para la caracterización de muestras tumorales en base a la detección de la presencia de moléculas superficiales mediante reacciones antigeno-anticuerpo (OTR2010-CT21 - Investigador)
    • Ayuda a la Consolidación del Grupo de Investigación CTS-600 (2009/CTS-600 - Investigador)
    • Ayuda a la Consolidación del Grupo de Investigación CTS-600 (2008/CTS-600 - Investigador)
    • Ayuda a la Consolidación del Grupo de Investigación CTS-600 (2007/CTS-600 - Investigador)

Cobertura de la base de datos de proyectos, véase aqui


Publicaciones:

Publicaciones en Revistas
Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Linares Clemente, Pedro, Rivero MC, et. al.:
Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of Cysteine String Protein-alpha (CSP-alpha). En: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019. Vol. 116. Núm. 16. Pag. 8000-8009

Servián Morilla, Emilia, Mavillard Saborido, Fabiola, Rivas Infante, Eloy, Nieto Gonzalez, Jose Luis, Rivero Mena, Maria del Carmen, et. al.:
A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss. En: EMBO Molecular Medicine. 2016. Vol. 8. Núm. 11. Pag. 1289-1309. 10.15252/emmm.201505815

Rozas Espadas, José Luis, Gómez Sánchez, Leonardo, Mircheski, Josif, Linares Clemente, Pedro, Nieto Gonzalez, Jose Luis, et. al.:
Motorneurons require cysteine string protein-alpha to maintain the readily releasable vesicular pool and synaptic vesicle recycling. En: Neuron. 2012. Vol. 74. Núm. 1. Pag. 151-165. 10.1016/j.neuron.2012.02.019

Rozas Espadas, José Luis, Gómez Sánchez, Leonardo, Tomas Zapico, Cristina, Lucas, Jose Javier, Fernandez Chacon, Rafael:
Increased Neurotransmitter Release At the Neuromuscular Junction in a Mouse Model of Polyglutamine Disease. Rozas Jl, Gómez-Sánchez L, Tomás-Zapico C, Lucas Jj, Fernández-Chacón R. J Neurosci. 2011 Jan 19;31(3):1106-13. En: Advances in Experimental Medicine and Biology. 2011. Vol. 31. Núm. 3. Pag. 1106-1113. 10.1523/¿Jneurosci.2011-10.2011

Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Gómez Sánchez, Leonardo, Linares Clemente, Pedro, Martínez López, José Antonio, et. al.:
Cysteine String Protein-Alpha Prevents Activity-Dependent Degeneration in Gabaergic Synapses. En: Advances in Experimental Medicine and Biology. 2010. Vol. 31. Núm. 21. Pag. 7377-7391. 10.1523/Jneurosci.0924-10.2010

Rozas Espadas, José Luis, Gómez Sánchez, Leonardo, Tomas Zapico, Cristina, Lucas, Jose Javier, Fernandez Chacon, Rafael:
Review/Reseña: Presynaptic Dysfunction in Huntington's Disease. En: Biochemical Society Transactions. 2010. Vol. 38. Núm. 2. Pag. 488-492

Aportaciones a Congresos
Muñoz Bravo, Jose Luis, Martínez López, José Antonio, Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Fernandez Chacon, Rafael:
Molecular co-chaperone Cysteine String Protein-alpha (CSP-alpha) controls mammalian target of rapamycin (mTOR) signaling in adult mouse fibroblasts. Poster en Congreso. IV Congreso Internacional de Investigación e Innovación en Enfermedades Neurodegenerativas (ciiien) de CIBERNED. Alicante, , - Valencia. 2016

Gómez Sánchez, Leonardo, Nieto Gonzalez, Jose Luis, Mavillard Saborido, Fabiola, Linares Clemente, Pedro, Pardal Redondo, Ricardo, et. al.:
Cysteine String Protein-alpha (CSP-alpha) maintains the postnatal quiescence of neural stem cells through inhibition of the mechanistic target of rapamycin (mTOR) signaling pathway. Poster en Congreso. IV Congreso Internacional de Investigación e Innovación en Enfermedades Neurodegenerativas (ciiien) de CIBERNED. Alicante, , - Valencia. 2016

Muñoz Bravo, Jose Luis, Martínez López, José Antonio, Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Fernandez Chacon, Rafael:
Molecular co-chaperone Cysteine String Protein-alpha (CSP-alpha) controls mammalian target of rapamycin (mTOR) signaling in adult mouse fibroblasts. Poster en Congreso. II Seville Molecular Medicine Workshop "Cell Therapy, Molecular Mechanisms and Clinical Translation". IBIS (Instituto de Biomedicina de Sevilla). 2016

Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Linares Clemente, Pedro, Pardal Redondo, Ricardo, et. al.:
CSP-ALFA maintains the quiescence of radial-glia like stem cells in postnatal neurogenesis. Poster en Congreso. ¿III Congreso Internacional de Investigación e Innovación en Enfermedades Neurodegenerativas (ciiien) de CIBERNED. Málaga. 2015

Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Linares Clemente, Pedro, Pardal Redondo, Ricardo, et. al.:
CSP-a is essential to maintains the quiescence of radial-glia like stem cells in adultl neurogenesis. Poster en Congreso. Development and Adult Neurogenesis in the Central Nervous System. Baeza, Jaen. 2015

Martínez López, José Antonio, Mavillard Saborido, Fabiola, Gómez Sánchez, Leonardo, Fernandez Chacon, Rafael:
Functional imaging of presynaptic calcium modulation mediated by metabotropic GABAB receptors. Poster en Congreso. Society for Neuroscience meeting 2014. Washington D.C. (USA). 2014

Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Linares Clemente, Pedro, Martínez López, José Antonio, et. al.:
CSP-a is essential to maintains the quiescence of radial-glia like stem cells in adultl neurogenesis¿. Poster en Congreso. Keyston Symposia: Adult neurogenesis. 2014

Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Linares Clemente, Pedro, Martínez López, José Antonio, et. al.:
CSP-A is essential to maintains the quiescence of radial-glia like stem cells in adultl neurogenesis. Poster en Congreso. X Simposio Internacional: Avances en la enfermedad de Alzheimer. Barcelona. 2014

Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Linares Clemente, Pedro, Martínez López, José Antonio, et. al.:
CSP-alpha is essential to maintain the quiescence of radial-glia like stem cells in postnatal neurogenesis. Poster en Congreso. XXXVII Congreso anual de la Sociedad Española de Bioquímica y Biología Molecular. Granada. 2014

Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Mircheski, Josif, Nieto Gonzalez, Jose Luis, Fernandez Chacon, Rafael:
Absence of Cysteine String Protein (CSP-Alpha) Cause a Strong Demyelination in the Central Nervous System. Poster en Congreso. IX Simposio Internacional: Avances en la Enfermedad de Alzehimer. 7º Foro Cientifico Ciberne. - Madrid, España. 2013

Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Martínez López, José Antonio, Mavillard Saborido, Fabiola, Fernandez Chacon, Rafael:
Altered Early Postnatal Neurogenesis At the Dentate Gyrus in CSP-Alpha Knock-Out Mice. Poster en Congreso. IX Simposio Internacional: Avances en la Enfermedad de Alzehimer. 7º Foro Cientifico Ciberne. 2013

Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Martínez López, José Antonio, Mavillard Saborido, Fabiola, Fernandez Chacon, Rafael:
Increased Froliferation in Newborn Cells and Synaptic Dysfunction At the Dentate Gyrus in CSP-Alpha Knoc-Out Mice. Poster en Congreso. New Frontiers in Neurodegeneratives Disease Research. Santa Fe, Nuevo Mexico, USA,. 2013

Gómez Sánchez, Leonardo, Mircheski, Josif, Mavillard Saborido, Fabiola, Nieto Gonzalez, Jose Luis, Fernandez Chacon, Rafael:
Absence of Cysteine String Protein-alpha (CSP-a) causes a strong demyelination in the central nervous system. Poster en Congreso. Membrane traffic at the synapse. The cell biology of synaptic plasticit. 2013

Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Martínez López, José Antonio, Mavillard Saborido, Fabiola, Linares Clemente, Pedro, et. al.:
Altered early postnatal neurogenesis at the dentate gyrus in CSP-alpha knock-out mice. Poster en Congreso. Membrane Traffic at the Synapse. The Cell Biology of Synaptic Plasticity. Workshops "Current Trends in Biomedicina. Baeza . Jaén. 2013

Gómez Sánchez, Leonardo, Mircheski, Josif, Nieto Gonzalez, Jose Luis, Fernandez Chacon, Rafael:
Absence of Cysteine String Protein-alpha (CSP-¿) causes a strong demyelination in the central nervous system. Poster en Congreso. Membrane Traffic at the Synapse. The Cell Biology of Synaptic Plasticity. Workshops "Current Trends in Biomedicina. Baeza . Jaén. 2013

Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Mircheski, Josif, Nieto Gonzalez, Jose Luis, Fernandez Chacon, Rafael:
Downregulated expression of genes involved in myelination in knock-out mice lacking Cysteine String Protein-alpha (CSP-a). Poster en Congreso. Neuroepigenetics: a New Perspective on Memory Mechanisms and Brain Disorders. Baeza, Jaen. 2012

Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Fernandez Chacon, Rafael:
Synaptic Dysfunction At the Dentate Gyrus in CSP¿ Knock-Out Mice, a Mouse Model of Neuronal Ceroid Lipofuscinosis. Poster en Congreso. 22 Congreso Internacional IUBMB y 37 Congreso Europeo FEBS. 2012

Gómez Sánchez, Leonardo:
Presynaptic degeneration at dentate gyrus in mice lacking Cysteine String Protein-alpha (CSP-alpha). Ponencia en Congreso. European Neuroscience Institute. . Barcelona, España. 2012

Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Mircheski, Josif, Nieto Gonzalez, Jose Luis, Fernandez Chacon, Rafael:
Downregulated Expression of Genes Involved in Myelination in Knock-Out Mice Lacking Cysteine String Protein-Alpha (CSP-Alpha). Poster en Congreso. 22 Congreso Internacional IUBMB y 37 Congreso Europeo FEBS. 2012

Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Fernandez Chacon, Rafael:
Synaptic Dysfunctions At the Dentate Gyrus in CSP-Alpha Knock-Out Mice. Poster en Congreso. Neuroepigenetics: a New Perspective on Memory Mechanisms and Brain Disorders. Baeza, Jaen. 2012

Gómez Sánchez, Leonardo, Mavillard Saborido, Fabiola, Mircheski, Josif, Nieto Gonzalez, Jose Luis, Fernandez Chacon, Rafael:
Downregulated expression of genes involved in myelination in knock-out mice lacking Cysteine String Protein-alpha (CSP-alpha). Poster en Congreso. EUSynapse Alumni Meeting. - Sevilla, ESPAÑA. 2012

Nieto Gonzalez, Jose Luis, Gómez Sánchez, Leonardo, Martínez López, José Antonio, Fernandez Chacon, Rafael:
Dysfunctional GABA release at the hippocampal basket-granule cell synapses in CSP-alpha knock-out mice. Poster en Congreso. EUSynapse Alumni Meeting. - Sevilla, ESPAÑA. 2012

Gómez Sánchez, Leonardo, Fernandez Chacon, Rafael:
Transcriptomics analysis of the hippocampus of knock-out mice lacking Cysteine String Protein-alpha (CSP-alpha), a mouse model of presynaptic degeneration. Poster en Congreso. Neuroscience 2011. Society for Neuroscienc. Washington, Estados Unidos. 2011

Rozas, José Luis, Gómez Sánchez, Leonardo, Linares Clemente, Pedro, Vázquez, M Eugenio, Lujan, Rafael, et. al.:
Cysteine string protein-alpha maintains the number of synaptic release sites and dynamin-dependent recycling at motor nerve terminals. Poster en Congreso. Neuroscience 2011. Society for Neurosciec. Washington, Estados Unidos. 2011

Gómez Sánchez, Leonardo, Fernandez Chacon, Rafael:
Transcriptomics analysis of the hippocampus of knock-out mice lacking Cysteine String Protein-alpha (CSP-alpha), a mouse model of presynaptic degeneration. Poster en Congreso. 5º Foro Ciberned. San Sebastian, España. 2011

Rozas Espadas, José Luis, Gómez Sánchez, Leonardo, Linares Clemente, Pedro, Vazquez, M Eugenio, Luján, Rafael, et. al.:
Cysteine string protein-alpha maintains the number of synaptic release sites and dynamin-dependent recycling at motor nerve terminals. Poster en Congreso. 5º Foro Ciberned. San Sebastian, España. 2011

Rozas Espadas, José Luis, Gómez Sánchez, Leonardo, Linares Clemente, Pedro, Vazquez, Eugenio, Fernandez Chacon, Rafael:
Disorders of the Synaptic Vesicle Cycle At the Neuromuscular Junction of Mice Lacking Cysteine String Protein Alpha. Poster en Congreso. XXXIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. Córdoba, España. 2010. XXXIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. 74. 74

Rozas Espadas, José Luis, Gómez Sánchez, Leonardo, Tomas Zapico, Cristina, Lucas, Jose Javier, Fernandez Chacon, Rafael:
Neurotransmitter Release Increase At Motoneuron Terminals in a Polyglutamine Disease Mouse Model. Poster en Congreso. Neuroscience 2010. San Diego (EEUU). 2010. Neuroscience 2010. 25. 26

Rozas Espadas, José Luis, Gómez Sánchez, Leonardo, Linares Clemente, Pedro, Vazquez, Eugenio, Lujan, Rafael, et. al.:
Cysteine String Protein-Alpha Maintains the Number of Synaptic Release Sites and Dynamin-Dependent Endocytosis At Motor Nerve Terminals. Poster en Congreso. 4º Foro Científico Ciberned. Santander, España. 2010. 4º Foro Científico Ciberned. 46. 46

Rozas Espadas, José Luis, Gómez Sánchez, Leonardo, Tomas Zapico, Cristina, Lucas, Jose Javier, Fernandez Chacon, Rafael:
Neurotransmitter Release Increase At Motoneuron Terminals in a Polyglutamine Disease Mouse Model. Poster en Congreso. 4º Foro Científico Ciberned. Santander, España. 2010. 4º Foro Científico Ciberned. 44. 44

Gómez Sánchez, Leonardo, Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Linares Clemente, Pedro, Lujan, Rafael, et. al.:
Presynaptic Degeneration of Hippocampal Interneurons in the Brain of Knock-Out Mice Lacking Cysteine String Protein-Alpha (CSP-Alpha). Poster en Congreso. Final Eninet Meeting. Crete, Greece. 2009. Network of European Neuroscience Institutes. 11. 12

Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Gómez Sánchez, Leonardo, Linares Clemente, Pedro, Lujan, Rafael, et. al.:
CSP-Alpha is Differentially Required by Gabaergic and Glutamatergic Hippocampal Synapses to Maintain Synaptic Function. Poster en Congreso. Final Eninet Meeting. Crete, Greece. 2009. Network of European Neuroscience Institutes. 12. 12

Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Gómez Sánchez, Leonardo, Linares Clemente, Pedro, Lujan, Rafael, et. al.:
Diferente Requerimiento de la Proteína CSP-Alpha en Sinapsis Gabaérgicas y Glutamatérgicas para Prevenir la Degeneración Sináptica Dependiente de Actividad. Poster en Congreso. XIII Congreso de la Sociedad Española de Neurociencia. Tarragona, España. 2009. XIII Congreso de la Sociedad Española de Neurociencia. 133. 134

Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Gómez Sánchez, Leonardo, Linares Clemente, Pedro, Lujan, Rafael, et. al.:
Cysteine String Protein-Alpha Prevents Activity-Dependent Degeneration in Gabaergic Synapses: Electrophysiological and Pharmacological Studies. Poster en Congreso. Actives Zones As Organizers of Neuronal Communication. Baeza, España. 2009. Actives Zones As Organizers of Neuronal Communication. 6. 6

Gómez Sánchez, Leonardo, Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Linares Clemente, Pedro, Lujan, Rafael, et. al.:
Cysteine String Protein-Alpha Prevents Activity-Dependent Degeneration in Gabaergic Synapses: Inmunohistochemical and Ultrastructural Studies. Poster en Congreso. Actives Zones As Organizers of Neuronal Communication. Baeza, España. 2009. Actives Zones As Organizers of Neuronal Communication. 7. 7

Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Linares Clemente, Pedro, Gómez Sánchez, Leonardo, Lujan, Rafael, et. al.:
Study of Synaptophaties At Hippocampal Neurons in Mice Lacking the Synaptic CO-Chaperone Cysteine String Protein-Alpha (CSP-Alpha). Poster en Congreso. Synaptophathies: Dysfunction of Synaptic Function. Cornwall, UK. 2009. Synaptophathies: Dysfunction of Synaptic Function. 11. 11

Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Linares Clemente, Pedro, Gómez Sánchez, Leonardo, Lujan, Rafael, et. al.:
CSP-Alpha is Required to Preferencially Prevent Neurodegeneration of Gabaergic Synapses in Cultured Hippocampal Neurons. Poster en Congreso. XXXV Congreso Secf. 2009. Acta Physiologica. 8. 8

Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Linares Clemente, Pedro, Gómez Sánchez, Leonardo, Fernandez Chacon, Rafael:
AMPA Receptor Downscaling and Neurodegeneration of Gabaergic Synapses in Cysteine String Protein-Alpha Deficient Hippocampal Neurons. Poster en Congreso. Fens Forum of European Neuroscience. Ginebra, Suiza. 2008. Fens Forum of European Neuroscience. 81. 81

Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Linares Clemente, Pedro, Gómez Sánchez, Leonardo, Fernandez Chacon, Rafael:
AMPA Receptor Downscaling and Neurodegeneration of Gabaergic Synapses in Cysteine String Protein-Alpha Deficient Hippocampal Neurons. Poster en Congreso. European Neuroscience Institute. Roma, Italia. 2008. European Neurosience Institute (Eni)-Net. 7. 7

Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Linares Clemente, Pedro, Gómez Sánchez, Leonardo, Fernandez Chacon, Rafael:
Presynaptic Activity in Cultured Hippocampal Neurons from Mice Lacking Cysteine String Protein-Á (CSP-Á). Poster en Congreso. European Neuroscience Institute. Varsovia, Polonia. 2008. European Neuroscience Institute (Eni)-Net Annual Meeting. 46. 46

Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Linares Clemente, Pedro, Gómez Sánchez, Leonardo, Fernandez Chacon, Rafael:
AMPA Receptor Downscaling and Neurodegeneration of Gabaergic Synapses in Cysteine String Protein-Alpha Deficient Hippocampal Neurons. Poster en Congreso. Gordon Research Conferences ¿Neurobiology of Brain Disorders¿. Oxford, Reino Unido. 2008. Gordon Research Conferences ¿Neurobiology of Brain Disorders¿. 15. 15

Garcia-Junco Clemente, Pablo Luis, Cantero, Gloria, Linares Clemente, Pedro, Gómez Sánchez, Leonardo, Fernandez Chacon, Rafael:
Downsizing of AMPA Mediated Mepscs and Reduction of Gabaergic Synapses in Cysteine String Protein-Alpha Deficient Hippocampal Neurons. Poster en Congreso. 10th Meeting of the European Calcium Society. Leuven, Belgica. 2008. 10th Meeting of the European Calcium Society. 56. 56

Vicerrectorado de Investigación. Universidad de Sevilla. Pabellón de Brasil. Paseo de las Delicias s/n. Sevilla