Francisco Manuel Vega Moreno
Telefono: 955923037
Email: Solicitar correo
Página personal: https://fmvega.wordpress.com/
Perfil en ORCID: 0000-0002-9015-864X
Perfil en WOS: C-4678-2008
Perfil en Scopus: 57190945608

Grupo de Investigación: Fisiopatología de Células Madre Neurales
Departamento/Unidad: Biología Celular
Situación profesional: Profesor Titular de Universidad

Responsable de los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Revelando señalización específica en células indiferenciadas de la cresta neural: nuevas oportunidades de tratamiento para el neuroblastoma agresivo (PID2022-142424OB-I00)
  • Heterogeneidad Celular Derivada de la Cresta Neural Simpatoadrenal: Implicaciones en la Progresión y el Tratamiento de los Neuroblastomas (PID2019-110817RB-I00)
  • Fisiopatología Celular y Molecular de los Neuroblastomas Agresivos (P18-RT-3151)
  • Fisiopatología Celular y Molecular de los Neuroblastomas Agresivos (US-1262985)
  
  

Participa en los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Fisiopatología de Células Madre Derivadas de la Cresta Neural (SAF2013-48535-P - Equipo de Investigación)
  • Physiology of the adult carotid body stem cell niche 260964 (260964 - Contratado)
  
  
• Contrato con empresas (Arts. 68/83 LOU):
  • High-throughput screening for novel rejuvenation factors (4368/1142 - Equipo Trabajo (Solicitud))
  
  
• Ayuda a la investigación:
  • Incentivo al Grupo de Investigación CTS-007 (2017/CTS-007 - Investigador)
  
  

Cobertura de la base de datos de proyectos, véase aqui

Publicaciones:

Capítulos en Libros

Francisco M Vega, Reymond, Nicolas, Ridley, Anne:
RhoC. Pag. 1664-1668. En: Encyclopedia of Signalling Molecules. Springer. 2018. ISBN 978-3-319-67198-7

Vega Moreno, Francisco Manuel:
VRK1:vaccinia-related kinase 1. Pag. 1992-1996. En: Encyclopedia of Signalling Molecules. 2012. ISBN 978-1-4419-0460-7

Vega Moreno, Francisco Manuel, Reymond, Nicolas, Ridley, Anne J.:
RhoC. Pag. 1664-1668. En: Encyclopedia of Signalling Molecules. 2012. ISBN 978-1-4419-0460-7

Publicaciones en Revistas

Colmenero Repiso, Ana, Gómez, María de los Ángeles, Rodriguez Prieto, Ismael, Rivas Infante, Eloy, Pardal Redondo, Ricardo, et. al.:
Identification of VRK1 as a New Neuroblastoma Tumor Progression Marker Regulating Cell Proliferation. En: Cancers. 2020. Vol. 12. Núm. 11

Huertas, Carlos, Gómez, María de los Ángeles, Pardal Redondo, Ricardo, Francisco M Vega:
Review/Reseña: Hypoxia in the Initiation and Progression of Neuroblastoma Tumours. En: International Journal of Molecular Sciences. 2019. Vol. 21. Núm. 1. Pag. 39-53

Linares Clemente, Pedro, Aguilar Morante, Diana, Rodriguez Prieto, Ismael, Ramirez Villar, Gema Lucia, De Torres, Carolina, et. al.:
Neural crest derived progenitor cells contribute to tumor stroma and aggressiveness in high-risk neuroblastoma. En: Oncotarget. 2017. Vol. 8. Núm. 52. Pag. 89775-89792. 10.18632/oncotarget.21128

Vega Moreno, Francisco Manuel, Gautier, Violette, Fernandez Ponce, Cecilia, Extremera, Maria Jesus, Altelaar, A.f.m., et. al.:
The atheroma plaque secretome stimulates the mobilization of endothelial progenitor cells ex vivo. En: Journal of Molecular and Cellular Cardiology. 2017. Vol. 105. Pag. 12-23. 10.1016/j.yjmcc.2017.02.001

Francisco M Vega, Ridley, Anne J.:
Review/Reseña: The RhoB small GTPase in physiology and disease. En: Small GTPases. 2016. Vol. Nov 2. Pag. 1-10. 10.1080/21541248.2016.1253528

Erdreich Epstein, Anat, Singh, Alok R., Joshi, Shweta, Francisco M Vega, Guo, Pinzheng, et. al.:
Association of high microvessel ¿vß3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126. En: Oncotarget. 2016. Vol. Nov 16. 10.18632/oncotarget.13386

Moura, David S., Fernandez, Isabel F., Marín Royo, Gema, López Sánchez, Inmaculada, Martín Doncel, Elena, et. al.:
Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation. En: Scientific Reports. 2016. Vol. 6. 10.1038/srep28532

Francisco M Vega, Reymond, Nicolas, Thomas, Marian, Ridley, Anne J.:
The Rho GTPase RhoB regulates cadherin expression and epithelial cell-cell interaction. En: Cell Communication and Signaling [electronic resource]. 2015. Vol. 13. Núm. 6

Mártinez Criado, Yolanda, Cabella, Rosa, Fernández Pineda, Israel, Vega, F.M.:
Study of the expression of neural stem cell markers in neuroblastoma tumor samples and correlation with prognostic factors. En: Cirugía Pediátrica. 2013. Vol. 3. Pag. 112-118

Vega Moreno, Francisco Manuel, Colomba, Audrey, Reymond, Nicolas, Thomas, Mairian, Ridley, Anne J.:
RhoB regulates cell migration through altered focal adhesion dynamics. En: Open Biology. 2012. Vol. 2. Núm. 5. 10.1186/s12964-015-0085-y

Reymond, Nicolas, Vega Moreno, Francisco Manuel, Ridley, Anne J.:
Cdc42 promotes transendothelial migration of cancer cells through BETA1 integrin. En: Journal of Cell Biology. 2012. Vol. 199. Núm. 4. Pag. 653-668

Vega Moreno, Francisco Manuel, Fruhwirth, G., Ng, Tony, Ridley, Anne J.:
RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. En: Journal of Cell Biology. 2011. Vol. 193. Núm. 4. Pag. 655-665

Valbuena, Alberto, Sanz García, Marta, López Sánchez, I., Vega Moreno, Francisco Manuel, Lazo, Pedro A.:
Review/Reseña: Roles of VRK1 as a new player in the control of biological processes required for cell division. En: Cellular Signalling. 2010. Vol. 23. Núm. 8. Pag. 1267-1272

Durán, María del Carmen, Vega Moreno, Francisco Manuel, Moreno Bueno, G., Artiga, M.j., Sánchez, L., et. al.:
Characterisation of tumoral markers correlated with ErbB2 (HER2/Neu) overexpression and metastasis in breast cancer. En: Proteomics. Clinical Applications. 2008. Vol. 2. Pag. 1313-1326

Valbuena, Alberto, Blanco, Sandra, Vega Moreno, Francisco Manuel, Lazo, Pedro A.:
The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53. En: PLoS One. 2008. Vol. 3. Núm. 7

Vega Moreno, Francisco Manuel, Ridley, Anne J.:
Review/Reseña: Rho GTPases in cancer cell biology. En: FEBS Letters. 2008. Vol. 582. Núm. 14. Pag. 2093-2101

Valbuena, Alberto, Lopez Sanchez, I., Vega Moreno, Francisco Manuel, Sevilla, Ana, Sanz García, Marta, et. al.:
Identification of a human epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations. En: Archives of Biochemistry and Biophysics. 2007. Vol. 465. Núm. 1. Pag. 219-226

Vega Moreno, Francisco Manuel, Ridley, Anne J.:
Review/Reseña: Snapshot: Rho family GTPases. En: Cell. 2007. Vol. 129. Núm. 7. Pag. 1430-1431

Valbuena, Alberto, Vega Moreno, Francisco Manuel, Lazo, Pedro A.:
p53 downregulates its activating vaccinia-related kinase 1 (VRK1) forming a new autoregulatory loop. En: Molecular and Cellular Biology. 2006. Vol. 26. Núm. 13. Pag. 4782-4793

Wheeler, A.p., Wells, C., Smith, S.d., Vega Moreno, Francisco Manuel, Herderson, R.b., et. al.:
Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. En: Journal of Cell Science. 2006. Vol. 19. Núm. 13. Pag. 2749-2757

Blanco, Sandra, Klimcakova, L., Vega Moreno, Francisco Manuel, Lazo, Pedro A.:
Subcellular localization of vaccinia-related kinase 2 (VRK2) isoforms determines their different effects on p53 stability in tumour cell lines. En: The FEBS Journal. 2006. Vol. 273. Núm. 1. Pag. 2487-2504

Santos, Claudio R., Rodriguez Pinilla, M., Vega Moreno, Francisco Manuel, Rodriguez Peralto, J.l., Blanco, Sandra, et. al.:
VRK1 Signaling pathway in the context of the proliferation phenotype in Head and Neck squamous cell carcinoma. En: Molecular Cancer Research. 2006. Vol. 4. Núm. 3. Pag. 177-185

Vega Moreno, Francisco Manuel, Sevilla, Ana, Lazo, Pedro A.:
p53 Stabilization and accumulation induced by human vaccinia-related kinase 1. En: Molecular and Cellular Biology. 2004. Vol. 24. Núm. 23. Pag. 10366-10380

Santos, Claudio R., Vega Moreno, Francisco Manuel, Blanco, Sandra, Barcia, Ramón, Lazo, Pedro A.:
The vaccinia virus B1R kinase induces p53 downregulation by and Mdm2-dependent mechanism. En: Virology. 2004. Vol. 328. Núm. 2. Pag. 254-265

Sevilla, Ana, Santos, Claudio R., Barcia, Ramón, Vega Moreno, Francisco Manuel, Lazo, Pedro A.:
c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK). En: Oncogene. 2004. Vol. 23. Núm. 55. Pag. 8950-8958

Sevilla, Ana, Santos, Claudio R., Vega Moreno, Francisco Manuel, Lazo, Pedro A.:
Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. En: Journal of Biological Chemistry. 2004. Vol. 279. Núm. 26. Pag. 27458-27465

Vega Moreno, Francisco Manuel, Gonzalo, P., Gaspar, Maria Luisa, Lazo, Pedro A.:
Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. En: FEBS Letters. 2003. Vol. 544. Pag. 176-180

Barcia, Ramón, Lopez Borges, Susana, Vega Moreno, Francisco Manuel, Lazo, Pedro A.:
Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1. En: Archives of Biochemistry and Biophysics. 2002. Vol. 399. Pag. 1-5

Martín Rubio, María Esther, Hidalgo Jimenez, Josefina, Vega Moreno, Francisco Manuel, Velasco Lopez, Angel:
Trimeric G proteins modulate the dynamic interaction of PKAII with the Golgi complex. En: Journal of Cell Science. 1999. Vol. 112. Núm. 22. Pag. 3869-3878

Aportaciones a Congresos

Vega Moreno, Francisco Manuel, Ridley, Anne J.:
Rho subfamily GTPases have distinct roles in migration and invasion by acting through different targets. Poster en Congreso. Frontiers in Cell Migration. Bethesda, EE.UU. 2011

Vega Moreno, Francisco Manuel:
Rho subfamily GTPases have distinct roles in migration and invasion by acting through different targets. Conferencia Congreso no publicada. Actin 2010 UK Meeting. Bristol , Reino Unido. 2010

Vega Moreno, Francisco Manuel, Ridley, Anne J.:
Rho GTPases isoforms specificity in tumor cell migration and invasion. Poster en Congreso. Beatson International Cancer Conference: Microenviroment, Motility and Metastasis. Glasgow - Reino Unido. 2009

Vega Moreno, Francisco Manuel:
Rho GTPases isoforms specificity in tumor cell migration and invasion. Conferencia Congreso no publicada. III Meeting in Cell Proliferation and Cancer. Mallorca, España. 2008

Vega Moreno, Francisco Manuel, Ridley, Anne J.:
Investigating the roles of Rho isoforms in tumor cell invasion and migration. Poster en Congreso. Keystone Symposia: Cell Migration in Invasion and Inflammation. Taos, New Mexico (EEUU). 2008

Vega Moreno, Francisco Manuel, Ridley, Anne J.:
Gene silencing technology for the study of Rho GTPases in tumor cell invasion and migration. Poster en Congreso. Gordon Research Conference: Mechanisms of Cell Signalling. 2007

Vega Moreno, Francisco Manuel:
Gene silencing technology for the study of Rho GTPases in tumor cell invasion. Conferencia Congreso no publicada. Actin 2006 UK meeting. Bristol , Reino Unido. 2006

Vega Moreno, Francisco Manuel, Ridley, Anne J.:
Gene silencing technology for the study of Rho GTPases in tumor cell invasion. Poster en Congreso. EMBO Worshop in Cell Migration, Tissue Invasion and Disease. Capri (Italia). 2006

Vega Moreno, Francisco Manuel:
The human kinase VRK1 and its role in the regulation of p53 tumor suppressor. Conferencia Congreso no publicada. XXVIII Congreso de la Sociedad española de Bioquimica y Biología Molecular (SEBBM). 2005

Vega Moreno, Francisco Manuel:
The human kinase VRK1 and its role in the regulation of p53 tumor suppressor. Conferencia en Exposición no publicada. III Symposio en Oncología: Apoptosis y Cáncer. 2004

Vega Moreno, Francisco Manuel, Lazo, Pedro A.:
p53 phosphorylation by the human vaccinia-related kinase 1 (VRK1). Poster en Congreso. International p53 workshop. 2002

Otras Publicaciones

Daza Navarro, Paula, Morón Monge, Hortensia, Martín Rubio, María Esther, Pastor Carrillo, Nuria María, Orta Vázquez, Manuel Luis, et. al.:
¿Cómo trabajar la ciencia en el huerto escolar?. Películas y Videograbaciones. 2020. Español

Tesis dirigidas y co-dirigidas:

Colmenero Repiso, Ana:
Papel de la quinasa humana VRK1 en la biología del neuroblastoma. Tesis Doctoral. 2020