María Dolores Navarro Hortal
Email: Solicitar correo
Perfil en ORCID: 0000-0002-6225-8379
Perfil en Scopus: 57202210427

Grupo de Investigación: Inmunonutrición e Inmunometabolismo
Departamento/Unidad: Bioquímica Médica y Biología Molecular e Inmunología
Situación profesional: Investigador Contratado (Juan dl Cierva)

Participa en los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Descrifrando el papel de los ácidos grasos de la dieta en la comunicación intercelular mediada por vesículas extracelulares y su implicación en la aterosclerosis y el síndrome metabólico: una aproximación multiómica para una nutrición de precisión (DIETEVOME) (PID2022-138650OA-I00 - Equipo Trabajo (Alta/Baja))
  
  

Cobertura de la base de datos de proyectos, véase aqui

Publicaciones:

Capítulos en Libros

Rivas García , Lorenzo, Navarro Hortal, María Dolores, Romero, José Manuel, Llopis González, Juan, Forbes, Tamara Yuliett, et. al.:
Valorization of Olea europaea and olive oil processing by-products/wastes. Pag. 193-212. En: Advances in Food and Nutrition Research. Elsevier. 2022. ISBN 78-0-323-99082-0

Quiles Morales, Jose Luis, Romero Márquez, José Manuel, Navarro Hortal, María Dolores, Battino, Maurizio, Varela López, Alfonso:
The role of coenzyme Q10 in the protection of bone health during aging. Pag. 173-182. En: Aging: Oxidative Stress and Dietary Antioxidants. Academic Press. Elsevier. 2020. ISBN 9780128186985

Quiles Morales, Jose Luis, Navarro Hortal, María Dolores, Battino, Maurizio, Forbes Hernández, Tamara Y., Ferreiro, M. Soledad, et. al.:
Efectos del aceite de oliva virgen sobre el envejecimiento. Pag. 77-91. En: Las bondades del consumo de aceite de oliva virgen. Ourense. Universidade de Vigo. 2019. ISBN 978-84-8158-835-4

Publicaciones en Revistas

Forbes, Tamara Yuliett, Vargas Corral, Franklin, Rivas García , Lorenzo, Bullón, Beatriz, Varela López, Alfonso, et. al.:
Addressing the physiopathology of periodontitis in older adults using an oleuropein-rich olive leaf supplement: Study design and baseline characteristics of the OLIVAGING clinical trial. En: Mediterranean Journal of Nutrition and Metabolism. 2025. Vol. 18. Pag. 215-223. 10.1177/1973798x251357485

Rivas García , Lorenzo, Crespo Antolín, Lara, Forbes, Tamara Yuliett, Romero, José Manuel, Navarro Hortal, María Dolores, et. al.:
Bioactive Properties of Tagetes erecta Edible Flowers: Polyphenol and Antioxidant Characterization and Therapeutic Activity against Ovarian Tumoral Cells and Caenorhabditis elegans Tauopathy. En: International Journal of Molecular Sciences. 2024. Vol. 25. https://doi.org/10.3390/ijms25010280

Romero, José Manuel, Navarro Hortal, María Dolores, Forbes, Tamara Yuliett, Varela López, Alfonso, Puentes Campos, Juan Gabriel, et. al.:
Exploring the Antioxidant, Neuroprotective, and Anti-Inflammatory Potential of Olive Leaf Extracts from Spain, Portugal, Greece, and Italy. En: Antioxidants. 2023. Vol. 12. Núm. 8. https://doi.org/10.3390/antiox12081538

Navarro Hortal, María Dolores, Forbes, Tamara Yuliett, Romero, José Manuel, Armas Díaz, Yasmany, Pascual Barrera, Alina e, et. al.:
Using the experimental model C. elegans to in vivo deepen into the biomedical properties of the Romina strawberry (Fragaria x ananassa) cultivar: A look into tau protein-related Alzheimer¿s disease, aging and redox biology. En: Journal of Berry Research. 2023. 10.3233/Jbr-230009

Romero, José Manuel, Navarro Hortal, María Dolores, Orantes, Francisco, Esteban, Adelaida, Perez Oleaga, Cristina, et. al.:
In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain. En: Antioxidants. 2023. Vol. 12. 10.3390/antiox12020404

Navarro Hortal, María Dolores, Romero, José Manuel, Muñoz Ollero, Pedro, Jiménez, Victoria, Esteban, Adelaida, et. al.:
Amyloid ß- but not Tau-induced neurotoxicity is suppressed by Manuka honey via HSP-16.2 and SKN-1/NRF2 pathways in an in vivo model of Alzheimer disease. En: Food & Function. 2022. Vol. 13. Pag. 11185-11199. https://doi.org/10.1039/D2FO01739C

Rivas García , Lorenzo, Romero, José Manuel, Navarro Hortal, María Dolores, Esteban, Adelaida, Giampieri, Francesca, et. al.:
Unravelling potential biomedical applications of the edible flower Tulbaghia violacea. En: Food Chemistry. 2022. Vol. 381. 10.1016/j.foodchem.2022.132096

García, Amalia, Rojas Macías, Sara, Rivas García , Lorenzo, Navarro Hortal, María Dolores, Romero, José Manuel, et. al.:
A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aß-induced toxicity in C. elegans. En: Chemical Communications. 2022. Vol. 58. Pag. 1514-1517. 10.1039/D1cc04404d

Navarro Hortal, María Dolores, Romero, José Manuel, Esteban, Adelaida, Sánchez González, Cristina, Rivas García , Lorenzo, et. al.:
Strawberry (Fragaria x ananassa cv. Romina) methanolic extract attenuates Alzheimer¿s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans. En: Food Chemistry. 2022. Vol. 372. 10.1016/j.foodchem.2021.131272

Romero, José Manuel, Badillo Carrasco, Alberto, Navarro Hortal, María Dolores, Rivas García , Lorenzo, Jiménez Trigo, Victoria, et. al.:
Nutritional interventions based on dietary restriction and nutrient reductions for the prevention of doxorubicin chemotherapy side effects. En: Mediterranean Journal of Nutrition and Metabolism. 2021. Vol. 14. Núm. 4. Pag. 427-438. 10.3233/Mnm-210020

Navarro Hortal, María Dolores, Romero, José Manuel, Varela López, Alfonso, Forbes Hernández, Tamara Y., Rivas García , Lorenzo, et. al.:
Strawberry phenolic extract increases lifespan in C. elegans. En: Acta Horticulturae. 2021. Núm. 1309. Pag. 995-1002. 10.17660/ActaHortic.2021.1309.141

Rivas García , Lorenzo, Romero, José Manuel, Navarro Hortal, María Dolores, Varela López, Alfonso, Forbes, Tamara, et. al.:
Changes in the content of metals of strawberry after preparation of phenolic-rich and anthocyanin-rich extracts for use in biomedicine and nutrition. En: Acta Horticulturae. 2021. Núm. 1309. Pag. 1303-1308. 10.17660/ActaHortic.2021.1309.142

Rivas García , Lorenzo, Quiles Morales, Jose Luis, Roma Rodrigues, Catarina, Raposo, Luis R., Navarro Hortal, María Dolores, et. al.:
Rosa x hybrida extracts with dual actions: antiproliferative effects against tumor cells and inhibitor of Alzheimer disease. En: Food and Chemical Toxicology. 2021. Vol. 149. 10.1016/j.fct.2021.112018

Rivas García , Lorenzo, Navarro Hortal, María Dolores, Romero, José Manuel, Forbes, Tamara, Varela López, Alfonso, et. al.:
Edible flowers as a health promoter: An evidence-based review. En: Trends in Food Science & Technology. 2021. Vol. 117. Pag. 46-59. 10.1016/j.tifs.2020.12.007

Navarro Hortal, María Dolores, Varela López, Alfonso, Romero Márquez, José M., Rivas García , Lorenzo, Speranza, Lorenza, et. al.:
Role of flavonoids against adriamycin toxicity. En: Food and Chemical Toxicology. 2020. Vol. 146. 10.1016/j.fct.2020.111820

Varela López, Alfonso, Battino, Maurizio, Navarro Hortal, María Dolores, Giampieri, Francesca, Forbes Hernández, Tamara Y., et. al.:
Review/Reseña: An update on the mechanisms related to cell death and toxicity of doxorubicin and the protective role of nutrients. En: Food and Chemical Toxicology. 2020. Vol. 139. 10.1016/j.fct.2019.110834

Quiles Morales, Jose Luis, Sánchez González, Cristina, Vera Ramírez, Laura, Giampieri, Francesca, Navarro Hortal, María Dolores, et. al.:
Review/Reseña: Reductive stress, bioactive compounds, redox-active metals, and dormant tumor cell biology to develop redox-based tools for the treatment of cancer. En: Antioxidants & Redox Signaling. 2020. 10.1089/ars.2020.8051

Romero Márquez, José Manuel, Navarro Hortal, María Dolores, Varela López, Alfonso, Osta, Safa, Eléxpuru Zabaleta, María, et. al.:
Usefulness of beeswax recycling by-products in the treatment of ß-amyloid toxicity in a C. elegans model of Alzheimer. En: Mediterranean Journal of Nutrition and Metabolism. 2020. Pag. 1-11. 10.3233/Mnm-200404

Varela López, Alfonso, Bullón Fernández, Pedro, Ramírez Tortosa, Cesar Luis, Navarro Hortal, María Dolores, Bullón , Beatriz, et. al.:
A diet rich in saturated fat and cholesterol aggravates the effect of bacterial lipopolysaccharide on alveolar bone loss in a rabbit model of periodontal disease. En: Nutrients. 2020. Vol. 12. Núm. 5. 10.3390/nu12051405

Toledano Perez, Manuel, Toledano, Manuel, Navarro Hortal, María Dolores, Varela López, Alfonso, Osorio Ruiz, Raquel, et. al.:
Novel polymeric nanocarriers reduced zinc and doxycycline toxicity in the nematode Caenorhabditis elegans. En: Antioxidants. 2019. Vol. 8. Núm. 11. 10.3390/antiox8110550

Navarro Hortal, María Dolores, Ramírez Tortosa, Cesar Luis, Varela López, Alfonso, Romero Márquez, José M, Ochoa Herrera, Julio Jose, et. al.:
Heart histopathology and mitochondrial ultrastructure in aged rats fed for 24 months on different unsaturated fats (virgin olive oil, sunflower oil or fish oil) and affected by different longevity. En: Nutrients. 2019. Vol. 11. Núm. 10. 10.3390/nu11102390

Navarro Hortal, María Dolores, Orantes Bermejo, Francisco, Sánchez González, Cristina, Varela López, Alfonso, Giampieri, Francesca, et. al.:
Industrial-scale decontamination procedure effects on the content of acaricides, heavy metals and antioxidant capacity of beeswax. En: Molecules. 2019. Vol. 24. Núm. 1518. 10.3390/molecules24081518

Navarro Hortal, María Dolores, Bernal Moreno, Cristina, Varela López, Alfonso:
Review/Reseña: Macronutrient effect on animal models of periodontal disease: a systematic review. En: Ars Pharmaceutica. 2018. Vol. 59. Núm. 4. Pag. 235-250. 10.30827/ars.v59i4.7317

Varela López, Alfonso, Navarro Hortal, María Dolores, Giampieri, Francesca, Bullón Fernández, Pedro, Battino, Maurizio:
Review/Reseña: Nutraceuticals in periodontal health: a systematic review on the role of vitamins in periodontal health maintenance. En: Molecules. 2018. Vol. 23. Núm. 5. 10.3390/molecules23051226

Aportaciones a Congresos

Quiles Morales, Jose Luis, Navarro Hortal, María Dolores, Romero, José Manuel, Sánchez González, Cristina, Llopis González, Juan, et. al.:
La miel de manuka inhibe la neurotoxicidad del peptido ß-amiloide en un modelo de Alzheimer. Comunicación en congreso. XI Congreso Nacional de Apicultura. Universidad de Málaga. 2023

Romero, José Manuel, Navarro Hortal, María Dolores, Orantes, Francisco, Sánchez González, Cristina, Jiménez Bermúdez, Marta, et. al.:
Propiedades antioxidantes y neuroprotectoras de una miel de aguacate proveniente del sur de España. Poster en Congreso. XI Congreso Nacional de Apicultura. Universidad de Málaga. 2023

Navarro Hortal, María Dolores, Forbes, Tamara Yuliett, Romero, José Manuel, Rivas García , Lorenzo, Giampieri, Francesca, et. al.:
In vitro and in vivo evaluation of four agroindustrial extracts (strawberry, oleuropein rich olive-leaves, garlic, broccoli) and manuka honey against Alzheimer`s disease. Poster en Congreso. 5th International conference on natural products utilization from plants to pharmacy shelf. Varna, Bulgaria. 2023

Rivas García , Lorenzo, Navarro Hortal, María Dolores, Romero, José Manuel, Llopis González, Juan, Quiles Morales, Jose Luis, et. al.:
The petals of tagetes erecta, a novel approximation against triple-negative breast cancer. Poster en Congreso. 5th International conference on natural products utilization from plants to pharmacy shelf. Varna, Bulgaria. 2023

Rivas García , Lorenzo, Romero, José Manuel, Navarro Hortal, María Dolores, Varela López, Alfonso, Forbes, Tamara, et. al.:
Changes in the content of metals of strawberry after preparation of phenolic-rich and anthocyanin-rich extracts for use in biomedicine and nutrition. Poster en Congreso. IX International Strawberry Symposium. Rimini, Italia. 2021

Navarro Hortal, María Dolores, Soria Castellano, Adrián, Romero Márquez, José M., Varela López, Alfonso, Forbes Henández, Tamara Y., et. al.:
Evaluación de los efectos preventivos de un extracto fenólico de fresa (Fragaria X ananassa) sobre alteraciones asociadas a la enfermedad de alzheimer en Caenorhabditis elegans. Poster en Congreso. I Congreso de Investigadores del PTS. Granada. 2019

Osorio Ruiz, Raquel, Quiles Morales, Jose Luis, Toledano Osorio, Manuel, Navarro Hortal, María Dolores, Varela López, Alfonso, et. al.:
A Caenorhabditis elegans model for testing toxicity of zinc and doxycycline loaded polymeric nanoparticles. Poster en Congreso. 13th International Conference on Frontiers in Biomedical Polymers. El Puerto de la Cruz (Tenerife). 2019

Varela López, Alfonso, Navarro Hortal, María Dolores:
Subproductos del recicaldo de cera previenen alteraciones asociadas al Alzheimer en el nematodo Caenorhabditis elegans. Poster en Congreso. IX Congreso Nacional de Apicultura. - Santa Cruz de Tenerife, España. 2018