Lin Gao Chen
Telefono: 955923033
Email: Solicitar correo
Perfil en ORCID: 0000-0002-1781-4671
Perfil en WOS: C-8318-2015
Perfil en Scopus: 56937463300

Grupo de Investigación: Fisiologia Celular y Biofisica
Departamento/Unidad: Fisiología Médica y Biofísica
Situación profesional: Profesor Titular de Universidad

Responsable de los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Eje Cuerpo Carotídeo-Médula Adrenal y Complicaciones cardiovasculares y Metabólicas Asociadas al Síndrome de Apnea Hipopnea del Sueño (US-1255654)
  • Sensibilidad al Oxígeno y Neurodegeneración (SAF2016-74990-R)
  
  

Participa en los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Sensibilidad a Oxígeno y Neurodegeneración (PID2019-106410RB-I00 - Equipo de Investigación)
  • Molecular mechanisms of acute oxygen sensing (OXYGENSENSING) (2629/0805 - Contratado)
  • Convenio de colaboración en materia de apoyo a la transferencia tecnológica en el campo de la biotecnología (CVFB12/005 - Investigador)
  • Sensibilidad al oxígeno y neurodegeneración (SAF2009-12409 - Otro Investigador)
  • Sensibilidad al oxígeno y neurodegeneración (CONFMB-001/2006 - Investigador)
  • Sensibilidad al oxígeno y neurodegeneración (SAF2006-08311 - Investigador)
  
  
• Ayuda a la investigación:
  • Incentivo al Grupo de Investigación CTS-516 (2011/CTS-516 - Investigador)
  • Ayuda a la Consolidación del Grupo de Investigación CTS-516 (2006/CTS-516 - Investigador)
  
  

Cobertura de la base de datos de proyectos, véase aqui

Publicaciones:

Capítulos en Libros

Lopez Barneo, Jose, Ortega Saenz, Gracia Patricia, Gao Chen, Lin, Caballero Eraso, Candelaria:
Testing Acute Oxygen Sensing in Genetically Modified Mice: Plethysmography and Amperometry. Pag. 139-153. En: Methods in molecular biology. Springer. 2018. ISBN 978-1-4939-7695-9

Publicaciones en Revistas

Gao Chen, Lin, Ortega Saenz, Gracia Patricia, Lopez Barneo, Jose:
Review/Reseña: Acute oxygen sensing-Role of metabolic specifications in peripheral chemoreceptor cells. En: Respiratory Physiology & Neurobiology. 2018. Vol. ID de PubMed:30172779. 10.1016/j.resp.2018.08.007

Arias Mayenco, Ignacio, González Rodríguez, Patricia, Torres Torrelo, Hortensia, Gao Chen, Lin, Fernández Agüera Rodríguez, Mª Carmen, et. al.:
Acute O-2 Sensing: Role of Coenzyme QH(2)/Q Ratio and Mitochondrial ROS Compartmentalization. En: Cell Metabolism. 2018. Vol. 28. Núm. 1. Pag. 145-158. 10.1016/j.cmet.2018.05.009

Ortega Saenz, Gracia Patricia, Caballero Eraso, Candelaria, Gao Chen, Lin:
Testing Acute Oxygen Sensing in Genetically Modified Mice: Plethysmography and Amperometry. En: Methods in Molecular Biology. 2018. Vol. 1742. Pag. 139-153. 10.1007/978-1-4939-7665-2_13.

Gao Chen, Lin, Bonilla Henao, Victoria Eugenia, García Flores, Gloria Paula, Arias Mayenco, Ignacio, Ortega Saenz, Gracia Patricia, et. al.:
Gene expression analyses reveal metabolic specifications in acute O2 -sensing chemoreceptor cells. En: The Journal of Physiology. 2017. Vol. 595. Núm. 18. Pag. 6091-6120. 10.1113/Jp274684

Gao Chen, Lin, González Rodríguez, Patricia, Ortega Saenz, Gracia Patricia, Lopez Barneo, Jose:
Review/Reseña: Redox signaling in acute oxygen sensing. En: Redox Biology. 2017. Vol. 12. Pag. 908-915. 10.1016/j.redox.2017.04.033

Vila Liante, Virtudes, Vila Liante, Virtudes, Martínez Sales, Vicenta, Ramón Nuñez, Luis, Arellano Orden, Elena, et. al.:
Impact of sample processing on the measurement of circulating microparticles: storage and centrifugation parameters. En: Clinical Chemistry and Laboratory Medicine. 2016. 10.1515/cclm-2016-0036

Lopez Barneo, Jose, Ortega Saenz, Gracia Patricia, González Rodríguez, Patricia, Fernández Agüera Rodríguez, Mª Carmen, Macias Gutierrez, David, et. al.:
Review/Reseña: Oxygen-sensing by arterial chemoreceptors: Mechanisms and medical translation. En: Molecular Aspects of Medicine. 2016. Vol. 47-48. Pag. 90-108. 10.1016/j.mam.2015.12.002.

Lopez Barneo, Jose, González Rodríguez, Patricia, Gao Chen, Lin, Fernández Agüera Rodríguez, Mª Carmen, Ortega Saenz, Gracia Patricia:
Review/Reseña: Oxygen Sensing by the Carotid Body: Mechanisms and Role in Adaptation to Hypoxia. En: American Journal of Physiology: Cell Physiology. 2016. Vol. 310. Núm. 8. 10.1152/ajpcell.00265.2015

Sanchez Lopez, Veronica, Vila Liante, Virtudes, Arellano Orden, Elena, Elías Hernández, Teresa, Ramón Nuñez, Luis, et. al.:
High correlation between 2 flow cytometry platforms in the microparticles analysis using a new calibrated beads strategy. En: Translational Research. 2015. 10.1016/j.trsl.2015.08.006

Fernández Agüera Rodríguez, Mª Carmen, Gao Chen, Lin, González Rodríguez, Patricia, Pintado Sanjuan, Carmelo Oscar, Arias Mayenco, Ignacio, et. al.:
Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling. En: Cell Metabolism. 2015. Vol. 22. Núm. 5. Pag. 825-837. 10.1016/j.cmet.2015.09.004.

Gao Chen, Lin, Ortega Saenz, Gracia Patricia, Garcia Fernandez, Maria, González Rodríguez, Patricia, Caballero Eraso, Candelaria, et. al.:
Review/Reseña: Glucose sensing by carotid body glomus cells: potential implications in disease. En: Frontiers in Physiology. 2014. Vol. 5. Núm. 398. Pag. 1-9. 10.3389/fphys.2014.00398. eCollection 2014

Gao Chen, Lin, Hidalgo Figueroa, María, Escudero Cuadrado, Luis María, Diaz Martin, Juan, Lopez Barneo, Jose, et. al.:
Age-mediated transcriptomic changes in adult mouse substantia nigra. En: PLoS One. 2013. Vol. 8. Pag. 1-12. 10.1371/journal.pone.0062456.s003

Gomez Garre, Maria del Pilar, Jesús Maestre, Silvia, Carrillo Garcia, Fatima, Caceres Redondo, Mayte, Bernal Bernal, Inmaculada, et. al.:
PSMC1 gene in Parkinson's disease. En: European Neurology. 2012. Vol. 68. Núm. 4. Pag. 193-198

Costa Martins, Alzenira de Fátima, Gao Chen, Lin, Carrillo Garcia, Fatima, Caceres Redondo, Mayte, Carballo Cordero, Manuel, et. al.:
Intermediate alleles at the FRAXA and FRAXE loci in Parkinson's disease. En: Parkinsonism & Related Disorders. 2011. Vol. 17. Núm. 4. Pag. 281-284. 10.1016/j.parkreldis.2010.12.013

Gao Chen, Lin, Diaz Martin, Juan, Dillmann, W, Lopez Barneo, Jose:
Heat shock protein 70 kDa over-expression and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigrostriatal degeneration in mice. En: Neuroscience. 2011. Vol. 193. Pag. 323-329

Gao Chen, Lin, Díaz Corrales, Francisco Javier, Carrillo Garcia, Fatima, Diaz Martin, Juan, Caceres Redondo, Mayte, et. al.:
Brain-derived neurotrophic factor G196A polymorphism and clinical features in Parkinson's disease. En: Acta Neurologica Scandinavica. 2010. Vol. 122. Núm. 1. Pag. 41-45

Romero Ruiz, Antonio, Mejias Estevez, Rebeca Maria, Diaz Martin, Juan, Lopez Barneo, Jose, Gao Chen, Lin:
Mesencephalic and striatal protein profiles in mice over-expressing glucose-6-phosphate dehydrogenase in dopaminergic neurons. En: Journal of Proteomics. 2010. Vol. 73. Núm. 9. Pag. 1747-1757

Gao Chen, Lin, Díaz Corrales, Francisco Javier, Carrillo Garcia, Fatima, Carballo Cordero, Manuel, Palomino García, Alfredo, et. al.:
Prevalence and clinical features of LRRK2 mutations in patients with Parkinson's disease in southern Spain. En: European Journal of Neurology. 2009. Vol. 16. Núm. 8. Pag. 957-960

Gao Chen, Lin, Mir Rivera, Pablo, Díaz Corrales, Francisco Javier, Mejias Estevez, Rebeca Maria, Carrillo Garcia, Fatima, et. al.:
Glucose-6-phosphate dehydrogenase activity in Parkinson's disease. En: Journal of Neurology. 2008. Vol. 255. Núm. 11. Pag. 1850-1851

Mejias, R, Mejias Estevez, Rebeca Maria, Villadiego Luque, Francisco Javier, Pintado Sanjuan, Carmelo Oscar, Pintado, O.C., et. al.:
Neuroprotection by Transgenic Expression of Glucose-6-Phosphate Dehydrogenase in Dopaminergic Nigrostriatal Neurons of Mice. En: Advances in Experimental Medicine and Biology. 2006. Vol. 26. Núm. 17. Pag. 4500-4508

Gao, Lin, Gao Chen, Lin, Mejias Estevez, Rebeca Maria, Echevarria Irusta, Miriam, Lopez Barneo, Jose, et. al.:
Induction of the Glucose-6-Phosphate Dehydrogenase Gene Expression by Chronic Hypoxia in Pc12 Cells. En: FEBS Letters. 2004. Vol. 569. Núm. 1-3. Pag. 256-260

Keeling, Km, Lanier, J, Du, M, Salas Marco, J, Gao Chen, Lin, et. al.:
Leaky Termination At Premature Stop Codons Antagonizes Nonsense-Mediated Mrna Decay in S. Cerevisiae. En: RNA. 2004. Vol. 10. Pag. 691-703

Gao Chen, Lin, Broughman, James, Iwamoto, Takeo, Tomich, John, Venglarik, Charles, et. al.:
Synthetic Chloride Channel Restores Glutathione Secretion in Cystic Fibrosis Airway Epithelia. En: American Journal of Physiology: Lung Cellular and Molecular Physiology. 2001. Vol. 281. Núm. 1

Gao Chen, Lin, Yankaskas, James, Fuller, Catherine, Sorscher, Eric, Matalon, Sadis, et. al.:
Chlorzoxazone or 1-Ebio Increases Na(+) Absorption Across Cystic Fibrosis Airway Epithelial Cells. En: American Journal of Physiology: Lung Cellular and Molecular Physiology. 2001. Vol. 281. Núm. 5

Gao Chen, Lin, Kim, Kj, Yankaskas, Jr, Forman, Henry J.:
Abnormal Glutathione Transport in Cystic Fibrosis Airway Epithelia. En: American Journal of Physiology. 1999. Vol. 277. Núm. 1

Liu, Rui Ming, Gao Chen, Lin, Choi, Jinah, Forman, Henry:
Gamma-Glutamylcysteine Synthetase: Mrna Stabilization and Independent Subunit Transcription by 4-Hydroxy-2-Nonenal. En: American Journal of Physiology. 1998. Vol. 275. Núm. 5

Zhou, Huanfang, Duncan, Roger, Robison, Timothy, Gao Chen, Lin, Forman, Henry:
CA(2+)-Dependent P47phox Translocation in Hydroperoxide Modulation of the Alveolar Macrophage Respiratory Burst. En: American Journal of Physiology. 1997. Vol. 273. Núm. 5

Aportaciones a Congresos

Cabello Rivera, Daniel, Ortega Saenz, Gracia Patricia, Gao Chen, Lin, Muñoz Cabello, Ana Maria, Bonilla Henao, Victoria Eugenia, et. al.:
Oxygen Regulation of Breathing is Abolished in Mitochondrial Complex III-Deficient Arterial Chemoreceptors. Poster en Curso. Bioenergetics for Brain Function. Bordeaux School of Neuroscience, Burdeos, Francia. 2022

Sanchez Lopez, Veronica, García Álvarez, Ana, Nuño Ayala , Mario, García Lunar, Inés, Arellano Orden, Elena, et. al.:
Hipertensión Pulmonar Postembólica en un Modelo Animal: Estudio Sobre el Papel de las Micropartículasn (Mps). Poster en Congreso. 50º Congreso Nacional de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR). Madrid. 2017

Sanchez Lopez, Veronica, García Álvarez, Ana, Nuño Ayala, Mario, García Lunar, Inés, Ferrer Galván, Marta, et. al.:
ESTUDIO SOBRE MICROPARTÍCULAS CIRCULANTES (MPs) EN UN MODELO EXPERIMENTAL DE HIPERTENSIÓN PULMONAR POSTROMBÓTICA. Poster en Congreso. LIX Congreso Nacional de la SEHH XXXIII Congreso Nacional de la SETH. Málaga. 2017

Ferrer Galván, Marta, Sanchez Lopez, Veronica, Arellano Orden, Elena, Gao Chen, Lin, Elias Hernandez, Teresa, et. al.:
Características Clínicas y Analíticas de los Pacientes con Cáncer que Desarrollan Eventos Trombóticos. Poster en Congreso. LIX Congreso Nacional de la SEHH XXXIII Congreso Nacional de la SETH. Málaga. 2017

Sanchez Lopez, Veronica, Ferrer Galván, Marta, Elias Hernandez, Teresa, Beato, Carmen, Arellano Orden, Elena, et. al.:
Estudio de Factores Procoagulantes en Pacientes con Cancer que Desarrollan Enfermedad Tromboembólica. Poster en Congreso. LVIII Congreso Nacional de la SEHH XXXII Congreso Nacional de la SETH. Santiago de Compostela. 2016

Sanchez Lopez, Veronica, Ferrer Galván, Marta, Elias Hernandez, Teresa, Arellano Orden, Elena, Jara Palomares L, et. al.:
EXPRESIÓN DIFERENCIAL DE MICROPARTICULAS CIRCULANTES (MPs) EN PACIENTES CON ENFERMEDAD TROMBOEMBOLICA VENOSA (ETV) Y PACIENTES CON CANCER. Poster en Congreso. LVIII Congreso Nacional de la SEHH XXXII Congreso Nacional de la SETH. Santiago de Compostela. 2016

Ferrer Galván, Marta, Arellano Orden, Elena, Otero Candelera, Remedios, Jara Palomares L, Sanchez Lopez, Veronica, et. al.:
Characterization of Microparticle Subpopulations in Cancer Patients With Thrombosis. Poster en Congreso. 23rd Biennial International Congress on Thrombosis. Valencia. 2014

Sanchez Lopez, Veronica, Vila Liante, Virtudes, Ramón Nuñez, Luis, Ferrer Galván, Marta, Elias Hernandez, Teresa, et. al.:
Correlations Using Two High-Sensitivity Flow Cytometers to Determine Positive Annexinv Microparticles (Mps) and Platelet-Derived Microparticles (Pmps) in Venous Thromboembolic Diseases (Vtd). Poster en Congreso. 23rd Biennial International Congress on Thrombosis. Valencia. 2014

Sanchez Lopez, Veronica, Vila Liante, Virtudes, Ferrer Galván, Marta, Elias Hernandez, Teresa, Arellano Orden, Elena, et. al.:
Cellular origin of circulating microparticles (MPs) in idiophatic venous thromboembolism and cancer. Poster en Congreso. 23rd Biennial International Congress on Thrombosis. Valencia. 2014

Gao Chen, Lin, Hidalgo Figueroa, María, Ortega de San Luis, Clara, Escudero Cuadrado, Luis María, Diaz Martin, Juan, et. al.:
Early age-mediated transcriptomal changes in mouse substantia nigra. Poster en Congreso. 22nd IUBMB and 37th FEBS Congress. Seville, Spain. 2012

Gao Chen, Lin, Hidalgo Figueroa, María, Ortega de San Luis, Clara, Escudero Cuadrado, Luis María, Diaz Martin, Juan, et. al.:
Early age-mediated transcriptomal changes in mouse substantia nigra. Poster en Congreso. 6º Foro CIBERNED. - Madrid, España, España. 2012

Gomez Garre, Maria del Pilar, Jesús Maestre, Silvia, Carrillo Garcia, Fatima, Caceres Redondo, Mayte, Gao Chen, Lin, et. al.:
PSMC1 gene in Parkinson's disease. Poster en Congreso. 15th International Congress of Parkinson¿s Disease and Movement Disorders. Toronto, Canada. 2011

Jesus Maestre,Silvia, Caceres Redondo, Mayte, Carrillo Garcia, Fatima, Gao Chen, Lin, Carballo Cordero, Manuel, et. al.:
El gen PSMC1 en la enfermedad de Parkinson. Comunicación en congreso. LXII Reunión Anual de la Sociedad Española de Neurología. 2010. Neurología. 105. 105

Mir Rivera, Pablo, Gao Chen, Lin, Díaz Corrales, Francisco Javier, Caceres Redondo, Mayte, Carballo Cordero, Manuel, et. al.:
Brain-Derived Neurotrophic Factor G196a Polymorphism and Clinical Features in Parkinson's Disease. Comunicación en congreso. 12th International Congress of Parkinson's Disease and Movement Disorders. Chicago. 2008. Movement Disorders. S48. S49

Mir Rivera, Pablo, Gao Chen, Lin, Díaz Corrales, Francisco Javier, Carrillo Garcia, Fatima, Carballo Cordero, Manuel, et. al.:
LRRK2 mutations in patients with Parkinson's disease in Southern Spain. Poster en Congreso. 11th International Congress of Parkinson¿S Disease and Movement Disorders. Istanbul, Turkey. 2007. Movement Disorders. S127. S127

Mir Rivera, Pablo, Gao Chen, Lin, Díaz Corrales, Francisco Javier, Mejias Estevez, Rebeca Maria, Vime, Pablo, et. al.:
Glucose-6-phosphate dehydrogenase in the peripheral blood of patients with Parkinson`s disease. Poster en Congreso. 11th International Congress of Parkinson¿S Disease and Movement Disorders. Istanbul, Turkey. 2007. Movement Disorders. S198. S199

Díaz Corrales, Francisco Javier, Gao Chen, Lin, Carrillo Garcia, Fatima, Carballo Cordero, Manuel, Diaz Martin, Juan, et. al.:
Prevalencia y características clínicas de la mutación LRRK2 en pacientes con enfermedad de Parkinson (EP) en el Sur de España. Comunicación en congreso. LIX Reunión de la Sociedad Española de Neurología. 2007. Neurologia. 647. 647

Gao Chen, Lin:
Neuroprotection by Transgenic Expression of Glucose-6-Phosphate Dehydrogenase in Dopaminergic Nigrostriatal Neurons of Mice. Poster en Congreso. Network of European Neuroscience Institutes:Christmas Meeting. Sevilla, España. 2006. Network of European Neuroscience Institutes:Christmas Meeting. 0. 0

Mejias, R, Villadiego Luque, Francisco Javier, Pintado, O.C., Vime, Pablo, Gao Chen, Lin, et. al.:
Neuroprotection in Transgenic Mice Overexpressing Glucosa-6-Phosphate Dehydrogenase in Dopaminergic Nigrostriatal Neurons. Poster en Congreso. 2nd Meeting on the Molecular Mechanisms of Neurodegeneration. Milan, Italia. 2005. 2nd Meeting on the Molecular Mechanisms of Neurodegeneration. 0. 0

Gao Chen, Lin, Bedwell, Dm:
New1p Regulates the Abundance of Both Nonsense-Containing and Wildtype Mrna But Does Not Affect Translation Termination in Saccharomyces Cerevisiae. Poster en Congreso. Annual Meeting Southeastern Branch American Society for Microbiology. Birmingham, Alabama, Eeuu. 2001. 2001 Annual Meeting Southeastern Branch American Society for Microbiology. 43. 43

Gao Chen, Lin, Broughman, Jr, Iwamoto, T, Tomich, Jm, Venglarik, C.J., et. al.:
Correction of Glutathione Secretion in Cystic Fibrosis Airway Epithelia by a Chloride Channel Forming Peptide and Chlorzoxazone. Poster en Congreso. Annual North American Cystic Fibrosis Conference. Baltimore, Maryland, Eeuu. 2000. Pediatric Pulmonology. 248. 248

Gao Chen, Lin, Yankaskas, Jr, Forman, Henry J., Venglarik, C.J.:
1-Ebio or Chlorzoxazone Increases Amiloride-Sensitive Na+ Absorption Across Cystic Fibrosis Airway Epithelial Cells. Poster en Congreso. Annual North American Cystic Fibrosis Conference. Baltimore, Maryland, Eeuu. 2000. Pediatric Pulmonology. 203. 203

Gao Chen, Lin, Kim, Kj, Yankaskas, Jr, Forman, Henry J.:
Abnormal Glutathione Transport in Cystic Fibrosis Airway Epithelia. Comunicación en congreso. Experimental Biology 1999. Washintong, D.C. Eeuu. 1999. The Faseb Journal. A1015. A1015

Gao Chen, Lin, Kim, Kj, Yankaskas, Jr, Forman, Henry J.:
Regulation of Glutathione Release in Cystic Fibrosis Airway Epithelia. Poster en Congreso. Annual North American Cystic Fibrosis Conference. Seattle, Washington, EEUU. 1999. Pediatric Pulmonology. 255. 255

Gao Chen, Lin, Kim, Kj, Forman, Henry J.:
Regulation of Glutathione Release in Cystic Fibrosis Airway Epithelia. Poster en Congreso. 6th Annual Meeting of the Oxygen Society. Estados Unidos. 1999. Free Radical Biology & Medicine. S60. S60

Gao Chen, Lin, Kim, Kj, Yankaskas, Jr, Forman, Henry J.:
Abnormal Glutathione (Gsh) Release Into Apical Fluid of Cystic Fibrosis Airway Epithelium. Poster en Congreso. The First International Conference on Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels. Shizuoka, Japon. 1999. The First International Conference on Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels. 0. 0

Gao Chen, Lin, Kim, Kj, Yankaskas, Jr, Forman, Henry J.:
Lung Epithelial Extracellular/Intracellular Glutathione Balance in Cystic Fibrosis. Comunicación en congreso. Annual North American Cystic Fibrosis Conference. Montreal, Canadá. 1998. Pediatric Pulmonology. 287. 287

Liu, Rm, Gao Chen, Lin, Choi, J, Forman, Henry J.:
Coordinate Regulation of Gama-Glutamylcysteine Synthetase Catalytic and Regulatory Subunit Gene Expression in Rat Lung Epithelial L2 Cells by 4-Hydroxy-2-Nonenal. Poster en Congreso. Oxygen Club of California. Santa Barbara, CA, Eeuu. 1998. Oxidants and Antioxidants in Biology. 137. 137

Tesis dirigidas y co-dirigidas:

Sanchez Lopez, Veronica:
Caracterización de subpoblaciones de micropartículas en pacientes con enfermedad tromboembólica venosa. Tesis Doctoral. 2017

(Doctorando no grabado)
Mecanismos moleculares de la sensibilidad aguda al oxígeno en los quimoreceptores arteriales: función del complejo I mitocondrial (Mª Carmen Fernández-Agüera Rodríguez). Tesis Doctoral. 2015