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Ficha personal - Belén Gómez González


Belén Gómez González
Telefono: 954467728
Email: Solicitar correo
Página personal: http://www.cabimer.es/web3/en/belen-gomez-gonzalez/
Perfil en ORCID: 0000-0003-1655-8407
Perfil en ResearcherID: B-2365-2014
Perfil en Scopus: 16678982400

Grupo de Investigación: Inestabilidad Genomica y Cancer
Departamento/Unidad: Genética
Situación profesional: Profesora Contratada Doctora Interina

Participa en los siguientes proyectos/ayudas en la US:

  • Proyecto de investigación:
    • Mecanismos de Inestabilidad Genómica Mediada por ARN y Reparación (PID2019-104270GB-I00 - Equipo de Investigación)
    • Respuesta transcriptional en cis a la presencia de daño en el DNA (P18-FR-655 - Equipo Trabajo (Solicitud))
    • Transcription y Replication como Fuentes de Inestabilidad Genética (BFU2016-75058-P - Equipo de Investigación)
    • Inestabilidad Genómica Asociada a Transcripción e Híbridos DNA-RNA (BFU2013-42918-P - Equipo Trabajo (Alta/Baja))
    • Bases Genéticas y Moleculares del Origen de la Inestabilidad Genomica en Eucariotas (P09-CVI-4567 - Otro Investigador)
    • Inestabilidad genómica (CSD2007-00015 - Investigador)
    • Genómica Funcional de la Interconexión Transcripción -Transporte de ARN (P07-CVI-02549 - Otro Investigador)
    • Bases genéticas y moleculares de la inestabilidad genómica y su relación con la biogénesis de los mRNPs de eucariotas (BFU2006-05260 - Otro Investigador)
    • Transcription-coupled homologous recombination (RG0075/1999-M - Becario)

  • Ayuda a la investigación:
    • Incentivo al Grupo de Investigación BIO-102 (2017/BIO-102 - Investigador)
    • Incentivo al Grupo de Investigación BIO-102 (2011/BIO-102 - Investigador)
    • Ayuda a la Consolidación del Grupo de Investigación BIO-102 (2008/BIO-102 - Investigador)
    • Ayuda a la Consolidación del Grupo de Investigación BIO-102 (2007/BIO-102 - Investigador)
    • Vigilancia del ARN nuclear en la expresión génica (BFU2007-28647-E - Contratado)
    • Ayuda a la Consolidación del Grupo de Investigación CVI-102 (2005/CVI-102)

Cobertura de la base de datos de proyectos, véase aqui


Publicaciones:

Capítulos en Libros
Gómez González, Belén, Ruiz Perez, Jose Francisco, Aguilera Lopez, Andres:
Genetic and Molecular Analysis of Mitotic Recombination in Saccharomyces Cerevisiae. Vol. 745. Pag. 151-172. En: DNA Recombination. Methods in Molecular Biology. H. Tsubouchi. 2011

Publicaciones en Revistas
Sessa, Gaetana, Gómez González, Belén, Silva, Sonia, Perez Calero, Carmen, Beaurepere, Romane, et. al.:
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair. En: EMBO Journal. 2021. 10.15252/embj.2020106018

Ortega, Pedro, García Pichardo, Desiré, San Martin Alonso, Marta, García Rondón, Ana, Gómez González, Belén, et. al.:
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage. En: Microbial cell. 2020. Vol. 7. Pag. 190-198. 10.15698/mic2020.07.723

Gómez González, Belén, Ortega, Pedro, Aguilera Lopez, Andres:
Histone deacetylases facilitate the accurate repair of broken forks. En: Molecular and Cellular Oncology. 2020. Vol. 7. Núm. (2). 10.1080/23723556.2019.1705731.

Gómez González, Belén, Barroso Ceballos, Sonia Ines, Herrera Moyano, Emilia, Aguilera Lopez, Andres:
Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle. En: Cell Cycle. 2020. Vol. 19. Núm. (5). Pag. 525-531. 10.1080/15384101.2020

Barroso Ceballos, Sonia Ines, Herrera Moyano, Emilia, Muñoz, Sergio, Garcia Rubio, Maria Luisa, Gómez González, Belén, et. al.:
The DNA damage response acts as a safeguard against harmful DNA-RNA hybrids of different origins. En: Embo Reports. 2019. Vol. 20. doi.org/10.15252/embr.201847250

Gómez González, Belén, Aguilera Lopez, Andres:
Review/Reseña: Transcription-mediated replication hindrance: a major driver of genome instability. En: Genes & Development. 2019. Vol. 33. Núm. 15-16. Pag. 1008-1026. 10.1101/gad.324517.119

Ortega, Pedro, Gómez González, Belén, Aguilera Lopez, Andres:
Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion. En: Nature Communications. 2019. Vol. 10. Núm. 1. 10.1038/s41467-019-13210-5

Gómez González, Belén:
Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways. En: Microbial cell. 2019. Vol. 6. Núm. 1. Pag. 1-64. 10.15698/mic2019.01.664

Gómez González, Belén, Patel, Harshil, Early, Anne, Diffley, John:
Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants. En: Genetics. 2019. 10.1534/genetics.118.301817

Lafuente Barquero, Juan, Luke Glaser, Sarah, Graf, Marco, Pinela, Sónia Cristina, Gómez González, Belén, et. al.:
The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage. En: PLoS Genetics. 2017. Vol. 13. Núm. 12. Pag. 1007136-1007136. 10.1371/journal.pgen.1007136

Gómez González, Belén, Aguilera Lopez, Andres:
The need to regulate replication fork speed. En: Science. 2017. Vol. 358. Núm. 6364. Pag. 722-723. 10.1126/science.aaq0678

García Pichardo, Desiré, Martínez, Juan Carlos, Garcia Rubio, Maria Luisa, Gómez González, Belén, García Rondón, Ana, et. al.:
Histone Mutants Separate R Loop Formation from Genome Instability Induction. En: Molecular Cell. 2017. Vol. 66. Núm. 5. Pag. 597-609. 10.1016/j.molcel.2017.05.014

Bhatia, Vaibhav, Herrera Moyano, Emilia, Herrera Moyano, Emilia, Aguilera Lopez, Andres, Gómez González, Belén:
The Role of Replication-Associated Repair Factors on R-Loops. En: Genes. 2017. Vol. 8. Núm. 7. 10.3390/genes8070171

Aguilera Lopez, Andres, Gómez González, Belén:
DNA-RNA hybrids: the risks of DNA breakage during transcription. En: Nature Structural and Molecular Biology. 2017. Vol. 24. Núm. 5. Pag. 439-443

Muñoz Galvan, Sandra, Garcia Rubio, Maria Luisa, Ortega, Pedro, Ruiz Perez, Jose Francisco, Jimeno Gonzalez, Sonia, et. al.:
A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination. En: PLoS Genetics. 2017. Vol. 13. Núm. 3

Yekezare, Mona, Gómez González, Belén, Diffley, John:
Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally. En: Journal of Cell Science. 2013. Vol. 126. Pag. 1297-1306

Mischo, Hannah, Gómez González, Belén, Grzechnik, Pawel, García Rondón, Ana, Wei, Wu, et. al.:
Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability. En: Molecular Cell. 2011. Vol. 41. Pag. 21-32

Bermejo, Rodrigo, Capra, Thelma, Jossen, Rachel, Colosio, Arianna, Frattini, Camilla, et. al.:
The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores. En: Cell. 2011. Vol. 146. Pag. 233-246

Ruiz Perez, Jose Francisco, Gómez González, Belén, Aguilera Lopez, Andres:
Aid Induces Double-Strand Breaks At Immunoglobulin Switch Regions and C-Myc Causing Chromosomal Translocations in Yeast THO Mutants. En: PLoS Genetics. 2011. Vol. 7. Núm. 2

Gómez González, Belén, Garcia Rubio, Maria Luisa, Bermejo, R, Gaillard, Helene, Shirahige, K, et. al.:
Genome-Wide Function of THO/TREX in Active Genes Prevents R-Loop-Dependent Replication Obstacles. En: EMBO Journal. 2011. Vol. 30. Núm. 15. Pag. 3106-3119

Domínguez Sánchez, María Salud, Barroso Ceballos, Sonia Ines, Gómez González, Belén, Luna Varo, Rosa Maria, Aguilera Lopez, Andres:
Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. En: PLoS Genetics. 2011. Vol. 7. Núm. 12. 10.1371/journal.pgen.1002386

Pardo, Benjamín, Gómez González, Belén, Aguilera Lopez, Andres:
Review/Reseña: DNA Double-Strand Break Repair: How to Fix a Broken Relationship. En: Cellular and Molecular Life Sciences. 2009. Vol. 66. Núm. 6. Pag. 1039-1056

Gómez González, Belén, Aguilera Lopez, Andres:
R-Loops Do Not Accumulate in Transcription-Defective Hpr1-101 Mutants: Implications for the Functional Role of THO/TREX. En: Nucleic Acids Research. 2009. Vol. 37. Núm. 13. Pag. 4315-4321

Ruiz Perez, Jose Francisco, Gómez González, Belén, Aguilera Lopez, Andres:
Chromosomal Translocations Caused by Either Pol32-Dependant or Independant Triparental Break-Induced Replication. En: Molecular and Cellular Biology. 2009. Vol. 29. Núm. 20. Pag. 5441-5454

Gómez González, Belén, Felipe Abrio, Irene, Aguilera Lopez, Andres:
The S-Phase Checkpoint is Required to Respond to R-Loops Accumulated in THO Mutants. En: Molecular and Cellular Biology. 2009. Vol. 29. Núm. 19. Pag. 5203-5213

Aguilera Lopez, Andres, Gómez González, Belén:
Review/Reseña: Genome Instability: a Mechanistic View of Its Causes and Consequences. En: Nature Reviews. Genetics. 2008. Vol. 9. Núm. 3. Pag. 204-217

González Aguilera, Cristina, Tous Rivera, Cristina, Gómez González, Belén, Huertas Sanchez, Pablo, Luna Varo, Rosa Maria, et. al.:
The Thp1-Sac3-Sus1-Cdc31 Complex Works in Transcription Elongation-Mrna Export Preventing RNA-Mediated Genome Instability. En: Molecular Biology of the Cell. 2008. Vol. 19. Núm. 10. Pag. 4310-4318

Gómez González, Belén, Aguilera Lopez, Andres:
Activation-Induced Cytidine Deaminase Action is Strongly Stimulated by Mutations of the THO Complex. En: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2007. Vol. 104. Núm. 20. Pag. 8409-8414

Gómez González, Belén:
Transcription-mediated replication hindrance: a major driver of genome instability

Gómez González, Belén:
Review/Reseña: genome instability: a mechanistic view of its causes and consequences

Gómez González, Belén:
The need to regulate replication fork speed

Aportaciones a Congresos
Perez, Carmen, Barroso Ceballos, Sonia Ines, Bayona, Aleix, Bassayote, G, San Martin Alonso, Marta, et. al.:
Factors and mechanisms preventing R loop-mediated genome instability. Comunicación en congreso. Chromosome Dynamics Meeting: Emerging Concepts in Chromosome Biology. Viena, Austria / Vienna. 2019

Gómez González, Belén, Barroso Ceballos, Sonia Ines, Perez, Carmen, Ehlen, Assa, Carreira, Aura, et. al.:
Understanding R loop-mediated genome instability in DDR deficient cells. Poster en Congreso. The DNA-damage response in cell physiology and disease. Cape Sounio, Grecia. 2019

Gómez González, Belén, Ortega, Pedro, Aguilera Lopez, Andres:
Histone deacetylases support repair of broken forks by promoting sister chromatid cohesion. Ponencia en Congreso. The FASEB Science Research Conference on Genetic Recombination and Genome Rearrangements. Steamboat Springs, Colorado EEUU. 2019

Salas Armenteros, Irene, Martínez, Juan Carlos, Gómez González, Belén, Luna Varo, Rosa Maria, Aguilera Lopez, Andres:
Role of Chromatin and the DNA damage response in RNA-mediated genome instability CONFERENCIA INVITADA. Ponencia en Congreso. Frontiers in DNA Repair Conference. Berlin, Alemania. 2016

Muñoz Galvan, Sandra, Garcia Rubio, Maria Luisa, Pardo, Benjamín, Ruiz Perez, Jose Francisco, Gómez González, Belén, et. al.:
New factor involved in recombination-mediated restart of broken forks. Ponencia en Congreso. Abcam-Mechanisms of Recombination 2016. Alicante, España. 2016

Salas Armenteros, Irene, Martínez, Juan Carlos, Gómez González, Belén, Luna Varo, Rosa Maria, Aguilera Lopez, Andres:
Role of Chromatin and the DNA damage response in RNA-mediated genome instability. Ponencia en Congreso. Environmental Mutagenesis and Genomics Society ¿ From Environment to [Epi] Genome and Back Again. Kansas City, USA. 2016

Gómez González, Belén, Diffley, John:
Deciphering the role of S-phase checkpoints in the stabilisation of replication forks. Poster en Congreso. EMBO Conference Series on DNA replication, chromosome segregation and cell division. Egham, REINO UNIDO. 2015

Gómez González, Belén, Diffley, John:
Deciphering the Role of S-Phase Checkpoints in the Stabilisation of Replication Forks. Poster en Congreso. Cshl Meeting on Eukaryotic DNA Replication and Genome Maintenance. Cold Spring Harbor. 2013

Domínguez Sánchez, María Salud, Barroso Ceballos, Sonia Ines, Gómez González, Belén, Luna Varo, Rosa Maria, Aguilera Lopez, Andres:
Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. Comunicación en congreso. The enemy within: Endogenous DNA damage as a source of cancer and ageing. Baeza. 2011

Gómez González, Belén, Aguilera Lopez, Andres:
Aid Induced Dsbs and Chromosomal Translocations in a Model Organism. Conferencia Congreso no publicada. International Aid Workshop : from Immune Diversification to Cancer. Estocolmo, Suecia. 2010. International Aid Workshop : from Immune Diversification to Cancer. 0. 0

Gómez González, Belén, Garcia Rubio, Maria Luisa, Tous Rivera, Cristina, Bermejo, R, Marin, a, et. al.:
An Ubiquitous Role of the THO/TREX Complex in Transcription All Over the Yeast Genome. Poster en Congreso. Embo Conference Series on Gene Transcription in Yeast. San Feliu de Guixols, España. 2010. Embo Conference Series on Gene Transcription in Yeast. 77. 77

Ruiz Perez, Jose Francisco, Gómez González, Belén, Aguilera Lopez, Andres:
R-Loop Dependant Transcription Impairment Can Result in Dsbs and Chromosomal Translocations in Yeast. Poster en Congreso. Embo Conference Series on Recombination and Connections to Sumo and Ubiquitin Modifications. Il Ciocco, Italia. 2010. Embo Conference Series on Recombination and Connections to Sumo and Ubiquitin Modifications. 0. 0

Gómez González, Belén, Felipe Abrio, Irene, Aguilera Lopez, Andres:
Transcription-Associated Genetic Instability: Role of S-Phase Checkpoints to Respond to R-Loops Accumulated in Yeast THO Mutants. Comunicación en congreso. DNA and Chromosomes 2009: Physical and Biological Approaches. Corcega, Francia. 2009. DNA and Chromosomes 2009: Physical and Biological Approaches. 0. 0

Gómez González, Belén, Felipe Abrio, Irene, Aguilera Lopez, Andres:
The S-Phase Checkpoint is Required to Respond to R-Loops Accumulated in THO Mutants. Comunicación en congreso. VII Reunion de la Red Española de Levadura. Escorial, España. 2009. VII Reunion de la Red Española de Levadura. 18. 18

Luna Varo, Rosa Maria, González Aguilera, Cristina, Tous Rivera, Cristina, Gómez González, Belén, Garcia Rubio, Maria Luisa, et. al.:
Biogenesis de Mrnps y Elongacion de la Transcripcion: Thsc y Nab2 en la Interfase Transcripcion y Transporte del Arnm (Or3). Comunicación en congreso. XXXVII Congreso de la Sociedad Española de Genetica. Torremolinos,Malaga. 2009. XXXVII Congreso de la Sociedad Española de Genetica. 0. 0

Gómez González, Belén, Felipe Abrio, Irene, Aguilera Lopez, Andres:
Transcription-Associated Genetic Instability: Role of S-Phase Checkpoints to Respond to R-Loops Accumulated in THO Yeast Mutants. Comunicación en congreso. Cantoblanco Workshops on Biology-Molecular Mechanisms of Genomic Stability. 2009. Cantoblanco Workshops on Biology-Molecular Mechanisms of Genomic Stability. 0. 0

Aguilera Lopez, Andres, Moriel Carretero, Maria, Gómez González, Belén:
Recombination-Mediated Genome Instability in Nucleotide Excision Repair and Mrnp Biogenesis Mutants in S. Cerevisiae. Conferencia Congreso no publicada. Cantoblanco Workshops on Biology-Molecular Mechanisms of Genomic Stability. 2009. Cantoblanco Workshops on Biology-Molecular Mechanisms of Genomic Stability. 0. 0

Gómez González, Belén, Moriel Carretero, Maria, Barroso Ceballos, Sonia Ines, Aguilera Lopez, Andres:
Recombination-Mediated Genome Instability in Mrnp Biogenesis-Export and Nucleotide Excision Repair Mutants in S. Cerevisiae. Conferencia Congreso no publicada. Conferences Jacques Monod on Biological Responses to DNA Damage. Roscoff, Francia. 2008. Conferences Jacques Monod on Biological Responses to DNA Damage. 51. 51

Ruiz Perez, Jose Francisco, Gómez González, Belén, Aguilera Lopez, Andres:
DSB-Induced Triparental Translocations Mediated by Bir. Comunicación en congreso. Conferences Jacques Monod on Biological Responses to DNA Damage. Roscoff, Francia. 2008. Conferences Jacques Monod on Biological Responses to DNA Damage. 123. 123

Gómez González, Belén, Felipe Abrio, Irene, Barroso Ceballos, Sonia Ines, Aguilera Lopez, Andres:
Transcription-Associated Genomic Instability Caused by Mrnp Biogenesis-Export Impairment in S. Cerevisiae. Comunicación en congreso. International Workshop of the Institute for Advanced Studies and the Israel Science Foundation on Genome Stability in Health and Disease. Israel. 2008. International Workshop of the Institute for Advanced Studies and the Israel Science Foundation on Genome Stability in Health and Disease. 000. 000

Felipe Abrio, Irene, Gómez González, Belén, Aguilera Lopez, Andres:
Transcription-Mediated Genetic Instability in S. Cerevisiae Mrnp Biogenesis Mutants. Comunicación en congreso. SEBBM XXXI Congreso Sociedad Española de Bioquímica y Biología Molecular. Bilbao, España. 2008. SEBBM XXXI Congreso Sociedad Española de Bioquímica y Biología Molecular. 169. 169

Gómez González, Belén, Felipe Abrio, Irene, Aguilera Lopez, Andres:
Transcription-Mediated Genetic Instability in S. Cerevisae. Comunicación en congreso. Embo Conference Series on Recombination Mechanism. Il Ciocco, Italia. 2008. Embo Conference Series on Recombination Mechanism. 0. 0

Luna Varo, Rosa Maria, González Aguilera, Cristina, Tous Rivera, Cristina, Gómez González, Belén, Aguilera Lopez, Andres:
Thp1-Sac3-Sus1 and Mex67 Works in Transcription Elongation-Mrna Export Preventing R-Loop Formation and Genome Instability. Comunicación en congreso. Reunión de la Red Española de Levaduras. El Escorial (Madrid). 2007. Reunión de la Red Española de Levaduras (Resúmenes). 0. 0

Luna Varo, Rosa Maria, González Aguilera, Cristina, Tous Rivera, Cristina, Gómez González, Belén, Aguilera Lopez, Andres:
Novel Insights Into the Connection of Transcription With RNA Export. Comunicación en congreso. Embo Workshop on Mechanisms of Nucleocytoplasmic Transport. Taormina Sicily. 2007. Embo Workshop on Mechanisms of Nucleocytoplasmic Transport. 0. 0

Gómez González, Belén, Ruiz Perez, Jose Francisco, Moriel Carretero, Maria, Felipe Abrio, Irene, Aguilera Lopez, Andres:
Transcription and Recombination Mediated Genetic Instability in S. Cerevisiae. Conferencia Congreso no publicada. Cnio Cancer Conferences. Links Between Cancer, Replication Stress and Genomic Integrity. 2007. Cnio Cancer Conferences. Links Between Cancer, Replication Stress and Genomic Integrity. 0. 0

Ruiz Perez, Jose Francisco, Gómez González, Belén, Aguilera Lopez, Andres:
Triparental Translocations Generated by Break-Induced Replication. Poster en Congreso. Cnio Cancer Conferences. Links Between Cancer, Replication Stress and Genomic Integrity. 2007. Cnio Cancer Conferences. Links Between Cancer, Replication Stress and Genomic Integrity. 0. 0

Gómez González, Belén, Moriel Carretero, Maria, Aguilera Lopez, Andres:
Transcription and Recombination-Mediated Genetic Instability in S. Cerevisae. Conferencia Congreso no publicada. Faseb Summer Research Conference on Genetic Recombinationm and Genome Rearrangements. Snowmass, CO, USA. 2005. Faseb Summer Research Conferences - Genetic Recombination & Genome Rearrangements. 0. 0

Gómez González, Belén, Aguilera Lopez, Andres:
Molecular Analysis of Transcription-Associated Recombination (TAR) Aand Mutation (Tam). Comunicación en congreso. XXII International Conference on Yeast Genetics and Molecular Biology. Bratislava, Eslovaquia. 2005. XXII International Conference on Yeast Genetics and Molecular Biology. 0. 0

Cortes Ledesma, Felipe, Wellinger, Ralf Erik, Prado Velasco, Jose Felix, Huertas Sanchez, Pablo, Gómez González, Belén, et. al.:
Genetic Control of the Incidence and the Mechanisms of Mitotic Recombination in Yeast. Comunicación en congreso. Faseb Summer Research Conference on Genetic Recombinationm and Genome Rearrangements. Snowmass, CO, USA. 2005. Faseb Summer Research Conference on Genetic Recombinationm and Genome Rearrangements. 0. 0

Aguilera Lopez, Andres, Gómez González, Belén:
Molecular Analysis of Transcription-Associated Recombination (TAR) and Mutation (Tam). Poster en Congreso. Unia Workshop on Coupling Between Transcription and RNA Processing. Baeza, Jaen. 2004. Mechanisms and Biological Consequences of Recombinational DNA Repair-Mediated Genome Instability. 0. 0

Gómez González, Belén, Aguilera Lopez, Andres:
Molecular Analysis of Transcription-Associated Recombination (TAR) Aand Mutation (Tam). Comunicación en congreso. International Conference on Yeast Genetics and Molecular Biology. Rimini, Italia. 1999. XIX International Conference on Yeast Genetics and Molecular Biology. 0. 0

Gómez González, Belén, Huertas Sanchez, Pablo, Wellinger, Ralf Erik, Garcia Rubio, Maria Luisa, Tous Rivera, Cristina, et. al.:
Mechanisms of Transcription-Associated Genetic Instability. Conferencia Congreso no publicada. Keystone Symposia on Molecular and Cellular Biology. Keystone. Estados Unidos. 1993. Genome Instability and Repair. 0. 0

Vicerrectorado de Investigación. Universidad de Sevilla. Pabellón de Brasil. Paseo de las Delicias s/n. Sevilla