» Investigación » SISIUS - Investigación en la USE

Lourdes María Varela Pérez
Email: Solicitar correo
Perfil en ORCID: 0000-0002-8875-6042
Perfil en ResearcherID: M-4860-2015
Perfil en Scopus: 26430145600

Grupo de Investigación: Fisiopatologia Molecular del Sistema Cardiovascular
Departamento/Unidad: Fisiología Médica y Biofísica
Situación profesional: Profesor Titular de Universidad

Responsable de los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Regulación metabotrópica de RhoA por los canales de Ca2+: Papel en la adhesión de leucocitos al endotelio y la vasorreactividad vascular en la hemorragia subaracnoidea aneurismática en humanos (US-1381231)
  
  
• Contrato con empresas (Arts. 68/83 LOU):
  • Evaluación del riesgo cardiovascular en pacientes obesos con tratamiento multidisciplinar (4131/1095)
  
  

Cobertura de la base de datos de proyectos, véase aqui

Publicaciones:

Capítulos en Libros

Grao Cruces, Elena, Varela Pérez, Lourdes Maria, Martín Rubio, María Esther, Bermudez Pulgarin, Beatriz, Montserrat de la Paz, Sergio:
High-Density Lipoproteins and Mediterranean Diet: A Systematic Review. Pag. 5-15. En: Dietary Influence on Nutritional Epidemiology, Public Health and Our Lifestyle. Basel. Mdpi. 2023. ISBN 978-3-0365-7713-5

Lopez Sergio, Bermudez Pulgarin, Beatriz, Montserrat de la Paz, Sergio, Pacheco, Yolanda M., Ortega Gómez, Almudena, et. al.:
Oleic Acid: The main Component of Olive Oil on Postprandial Metabolic Processes. Pag. 639-649. En: Olives and Olive Oil in Health and Disease Prevention. Oxford. United Kingdom. Oxford: Academic Press. 2020. ISBN 978-0-12-819528-4

Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Bermudez Pulgarin, Beatriz, Lopez Sergio, Abia Gonzalez, María Rocío, et. al.:
Nutrigenomics and Atherosclerosis: The Postprandial and Long-Term Effects of Virgin Olive Oil Ingestion. Pag. 135-160. En: Atherogenesis. In Tech. 2011

Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Lopez Sergio, García Muriana, Francisco Jose, Abia Gonzalez, María Rocío:
Nutrigenomics and Atherosclerosis: the Postprandial and Long-Term Effects of Virgin Olive Oil Ingestion. Pag. 135-160. En: Atherogenesis. In Tech. 2011

Varela Pérez, Lourdes Maria, Ortega Gómez, Almudena, Lopez Sergio, Abia Gonzalez, María Rocío, García Muriana, Francisco Jose:
Beyond Dietary Fatty Acids As Energy Source: a Point of View for the Prevention and Management of Type 2 Diabetes. Pag. 311-320. En: Role of the Adipocyte in Development of Type 2 Diabetes. 2011

Varela Pérez, Lourdes Maria, Ortega Gómez, Almudena, Lopez Sergio, Bermudez Pulgarin, Beatriz, Abia Gonzalez, María Rocío, et. al.:
Beyond Dietary Fatty Acids As Energy Source: a Point of View for the Prevention and Management of Type 2 Diabetes. Pag. 311-320. En: Role of the Adipocyte in Development of Type 2 Diabetes. 2011. ISBN 978-953-307-598-3

Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Lopez Sergio, Pacheco Lopez, Yolanda María, Villar Ortiz, Jose Ricardo, et. al.:
Olive Oil is Superior to Other Dietary Fats for Arresting Cardiovascular Risk in the Fed State. a Lipid and Comprehensive Perspective. Pag. 1-19. En: Olive Oil and Health. Hauppauge, NY. Nova Sciences. 2010. ISBN 978-1-61761-170-4

Lopez Sergio, Pacheco Lopez, Yolanda María, Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Abia Gonzalez, María Rocío, et. al.:
Oleic Acid: the Main Component of Olive Oil on Postprandial Metabolic Processes. Pag. 1385-1393. En: Olives and Olive Oil in Health and Disease Prevention. 2010. ISBN 978-0-12-374420-3

Lopez Martin, Sergio, Bermudez Pulgarin, Beatriz, Pacheco Lopez, Yolanda María, Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, et. al.:
Oleic Acid: the Main Component of Olive Oil on Postprandial Metabolic Processes. Pag. 1385-1393. En: OLIVES AND OLIVE OIL IN HEALTH AND DISEASE PREVENTION. Elsevier Academic Press. San Diego. Academic Press Inc Elsevier Science. 2010. ISBN 978-0-12-374420-3

Publicaciones en Revistas

Revilla González, Gonzalo, Varela Pérez, Lourdes Maria, Ruiz de Azúa López, Zaida, Amaya Villar, Rosario, Pezzotti, Maria Rosa, et. al.:
Changes in adhesion and the expression of adhesion molecules in PBMCs after aneurysmal subarachnoid hemorrhage: relation to cerebral vasospasm. En: Translational Stroke Research. 2023. Vol. 15. Núm. 2. Pag. 378-387. 10.1007/s12975-023-01136-6

Martín Rubio, María Esther, Grao Cruces, Elena, Millán Linares, Mª Carmen, Varela Pérez, Lourdes Maria, Bermudez Pulgarin, Beatriz, et. al.:
Meeting-Abstract: Deciphering the role of dietary fatty acids on HDL (high-density lipoprotein) lipidome. En: Annals of Nutrition & Metabolism. 2023. Vol. 79. Pag. 683-683. https://www.webofscience.com/wos/woscc/full-record/WOS:001084581003144

Pérez Alegre, Mónica, Gallego Durán, Rocío, Rojas González, Ana Isabel, Martín Bermudo, Francisco, Varela Pérez, Lourdes Maria, et. al.:
Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr-/- Leidem mice without attenuation of steatohepatitis. En: Scientific Reports. 2021. Vol. 11. 10.1038/s41598-021-87761-3

Grao Cruces, Elena, Varela Pérez, Lourdes Maria:
High-Density Lipoproteins and Mediterranean Diet: A Systematic Review. En: Nutrients. 2021. Vol. 13

Grao Cruces, Elena, Varela Pérez, Lourdes Maria, Martín Rubio, María Esther, Bermudez Pulgarin, Beatriz, Montserrat de la Paz, Sergio:
High-Density Lipoproteins and Mediterranean Diet: A Systematic Review. En: Nutrients. 2021. Vol. 13

Lemus , Ana, Grao Cruces, Elena, Toscano, Rocio, Varela Pérez, Lourdes Maria, Claro Cala, Carmen Maria, et. al.:
A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice. En: Food & Function. 2020. Vol. 11. Pag. 2943-2952

Jurado Ruiz, Enrique, Álvarez Amor, Leticia, Varela Pérez, Lourdes Maria, Berná Amorós, Genoveva, Parra Camacho, María Soledad, et. al.:
Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice. En: Scientific Reports. 2019. Vol. 9. Núm. 11311. 10.1038/s41598-019-47904-z

Luque, Amparo, Álvarez, Leticia, Kleeman, Robert, Martín Bermudo, Francisco, Varela Pérez, Lourdes Maria:
Extra-Virgin Olive Oil with Natural Phenolic Content Exerts an Anti-Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr¿/¿.Leiden Mice. En: Molecular Nutrition & Food Research. 2018. Vol. 62. Núm. 13. https://doi.org/10.1002/mnfr.201800295

Bermudez Pulgarin, Beatriz, Dahl, Tuva, Medina, Indira, Groeneweg, Mathijs, Holm, Sverre, et. al.:
Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPAR¿-Dependent Monocyte Differentiation and Function. En: Arteriosclerosis, Thrombosis, and Vascular Biology. 2017. Vol. 37. Núm. 6. Pag. 1157-1167. doi: 10.1161/ATVBAHA.116.308187

Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Lopez Sergio, Montserrat de la Paz, Sergio, Sanchez, Rosario, et. al.:
Postprandial triglyceride-rich lipoproteins promote lipid accumulation and apolipoprotein B-48 receptor transcriptional activity in human circulating and murine bone marrow neutrophils in a fatty acid-dependent manner. En: Molecular Nutrition & Food Research. 2017. 10.1002/mnfr.201600879

Jurado Ruiz, Enrique, Varela Pérez, Lourdes Maria, Luque, Amparo, Martínez Force, Enrique, Gallego Durán, Rocío, et. al.:
An extra virgin olive oil-rich diet intervention ameliorates the non-alcoholic steatohepatitis induced by a high-fat ¿Western type¿ diet in mice. En: Molecular Nutrition & Food Research. 2017. Vol. 61. Núm. 3. Pag. 1600549_1-1600549_12. 10.1002/mnfr.201600549

Vilahur , G, Gutierrez, M, Casani, L, Varela Pérez, Lourdes Maria, Capdevilla, a, et. al.:
Letters: Response by Vilahur et al to Letters Regarding Article, "Protective Effects of Ticagrelor on Myocardial Injury After Infarction". En: Circulation. 2017. Vol. 135. Núm. 17. 10.1161/Circulationaha.117.027588

Bermudez Pulgarin, Beatriz, Dahl, Tb, Medina, I, Groeneweg, M, Holm, S, et. al.:
Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARg-Dependent Monocyte Differentiation and Function. En: Arteriosclerosis, Thrombosis, and Vascular Biology. 2017. 10.1161/Atvbaha.116.308187

Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Lopez Sergio, Montserrat de la Paz, Sergio, Sanchez, Rosario, et. al.:
Postprandial triglyceride-rich lipoproteins promote lipid accumulation and apolipoprotein B-48 receptor transcriptional activity in human circulating and murine bone marrow neutrophils in a fatty acid-dependent manner. En: Molecular Nutrition & Food Research. 2017. Pag. 1-12. 10.1002/mnfr.201600879

Vilahur, Gemma, Gutiérrez, M, Casani, L, Varela Pérez, Lourdes Maria, Capdevila, a, et. al.:
Protective Effects of Ticagrelor on Myocardial Injury After Infarction. En: Circulation. 2016. Vol. 134. Núm. 2. Pag. 1708-1719. 10.1161/Circulationaha.116.024014

Varela Pérez, Lourdes Maria, Lopez Sergio, Ortega Gómez, Almudena, Bermudez Pulgarin, Beatriz, Buers, I, et. al.:
Postprandial triglyceride-rich lipoproteins regulate perilipin-2 and perilipin-3 lipid-droplet-associated proteins in macrophages. En: The Journal of Nutritional Biochemistry. 2015. Vol. 26. Núm. 4. Pag. 327-336

Lopez Sergio, Jaramillo Carmona, Sara, Varela Pérez, Lourdes Maria, Ortega Gómez, Almudena, Abia Gonzalez, María Rocío, et. al.:
Review/Reseña: Membrane composition and dynamics: a target of bioactive olive oil constituents. En: Biochimica et Biophysica Acta (BBA). Biomembranes. 2014. Vol. 1838. Núm. 6. Pag. 1638-1656. 10.1016/j.bbamem.2014.01.007.

Montserrat de la Paz, Sergio, Lopez Sergio, Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Abia Gonzalez, María Rocío, et. al.:
Review/Reseña: Dietary fatty acids and vitamin b3: an effective treatment strategy for the metabolic syndrome?. En: Journal of Food & Nutritional Disorders. 2014. Vol. 3. 10.4172/2324-9323.1000157

Varela Pérez, Lourdes Maria, Bermudez Pulgarin, Beatriz, Ortega Gómez, Almudena, Lopez Martin, Sergio, Sánchez, Rosario, et. al.:
Postprandial triglyceride-rich lipoproteins promote invasion of human coronary artery smooth muscle cells in a fatty-acid manner through PI3k-Rac1-JNK signaling. En: Molecular Nutrition & Food Research. 2014. Vol. 58. Pag. 1349-1364. 10.1002/mnfr.201300749

Bermudez Pulgarin, Beatriz, Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Villar Ortiz, Jose Ricardo, Abia Gonzalez, María Rocío, et. al.:
Clustering effects on postprandial insulin secretion and sensitivity in response to meals with different fatty acid compositions. En: Food & Function. 2014. Vol. 5. Núm. 7. Pag. 1374-1380. 10.1039/c4fo00067f

Bermudez Pulgarin, Beatriz, Montserrat de la Paz, Sergio, Dahl, T, Medina, Indira, Lopez Sergio, et. al.:
Meeting-Abstract: Intracellular NAMPT protects against atherosclerosis in a PPAR¿-dependent manner. En: Basic & Clinical Pharmacology & Toxicology. 2013. Vol. 113

Varela Pérez, Lourdes Maria, Ortega Gómez, Almudena, Lopez Sergio, Abia Gonzalez, María Rocío, García Muriana, Francisco Jose, et. al.:
The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein/apoB48 receptor axis in human monocyte/macrophage cells. En: The Journal of Nutritional Biochemistry. 2013. Vol. 24. Núm. 12. Pag. 2031-2039

Tran Dinh, a, Diallo , D, Delbosc, S, Varela Pérez, Lourdes Maria, Dang, Qb, et. al.:
Review/Reseña: HDL and endothelial protection. En: British Journal of Pharmacology. 2013. Vol. 169. Núm. 3. Pag. 493-511. 10.1111/bph.12174

Lopez Sergio, Jaramillo Carmona, Sara, Varela Pérez, Lourdes Maria, Ortega Gómez, Almudena, Abia Gonzalez, María Rocío, et. al.:
p38 MAPK protects human monocytes from postprandial triglyceride-rich lipoprotein-induced toxicity. En: The Journal of Nutrition. 2013. Vol. 143. Núm. 5. Pag. 620-626. 10.3945/¿jn.113.174656

Lopez Martin, Sergio, Varela Pérez, Lourdes Maria, Ortega Gómez, Almudena, Pacheco Lopez, Yolanda María, Moreda Martino, Wenceslao, et. al.:
Triglyceride-Rich Lipoprotein Regulates APOB48 Receptor Gene Expression in Human THP-1 Monocytes and Macrophages. En: The Journal of Nutrition. 2012. Vol. 142. Núm. 2. Pag. 227-232. 10.3945/jn.111.149963

Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Bermudez Pulgarin, Beatriz, Lopez Martin, Sergio, Abia Gonzalez, María Rocío, et. al.:
Review/Reseña: Dietary fatty acids linking postprandial metabolic response and chronic diseases. En: Food & Function. 2012. Vol. 3. Núm. 1. Pag. 22-27. 10.1039/C1fo10085h

Lopez Martin, Sergio, Bermudez Pulgarin, Beatriz, Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Pacheco Lopez, Yolanda María, et. al.:
Effects of Meals Rich in Either Monounsaturated or Saturated Fat on Lipid Concentrations and on Insulin Secretion and Action in Subjects With High Fasting Triglyceride Concentrations. En: The American Journal of Clinical Nutrition. 2011. Vol. 93. Núm. 3. Pag. 494-499

Varela Pérez, Lourdes Maria, Ortega Gómez, Almudena, Bermudez Pulgarin, Beatriz, Lopez Martin, Sergio, Pacheco Lopez, Yolanda María, et. al.:
A High-Fat Meal Promotes Lipid-Load and Apolipoprotein B-48 Receptor Transcriptional Activity in Circulating Monocytes. En: The American Journal of Clinical Nutrition. 2011. Vol. 93. Pag. 918-925

Jaramillo Carmona, Sara, Lopez Martin, Sergio, Varela Pérez, Lourdes Maria, Rodriguez Arcos, Rocio, Jiménez Araujo, Ana José, et. al.:
The Flavonol Isorhamnetin Exhibits Cytotoxic Effects on Human Colon Cancer Cells. En: Journal of Agricultural and Food Chemistry. 2010. Vol. 58. Pag. 10869-10875. 10.1021/jf102669p

Lopez Martin, Sergio, Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Bermudez Pulgarin, Beatriz, García Muriana, Francisco Jose, et. al.:
Review/Reseña: Recent Advances in Lipoproteins and Atherosclerosis: a Nutrigenomic Approach. En: Grasas y Aceites. 2009. Vol. 60. Núm. 1. Pag. 33-40

Aportaciones a Congresos

Martín Rubio, María Esther, Grao Cruces, Elena, Millán Linares, Mª Carmen, Varela Pérez, Lourdes Maria, Bermudez Pulgarin, Beatriz, et. al.:
Deciphering the role of dietary fatty acids on HDL (highdensity lipoprotein) lipidome. Poster en Congreso. 22nd IUNS-International Congress of Nutrition (ICN). Tokyo, Japón. 2022

Grao Cruces, Elena, Lemus , Ana, Millán Linares, Mª Carmen, Toscano, Rocio, Varela Pérez, Lourdes Maria, et. al.:
Lupine (Lupinus angustifolius L.) peptide prevents non-alcoholic fatty liver disease in high-fat diet-induced obese mice. Comunicación en congreso. XI Runión de Jóvenes Farmacólogos de Andalucía. Málaga. 2019

Lemus , Ana, Grao Cruces, Elena, Millán Linares, Mª Carmen, Toscano, Rocio, Varela Pérez, Lourdes Maria, et. al.:
Lupine (Lupinos angustifolious L.) peptide ameliorates the non-alcoholic steatohepatitis in mice. Poster en Congreso. 39th Spanish Society of Pharmacology Meeting. Las Palmas de Gran Canarias (España). 2019

Álvarez, Leticia, Berná Amorós, Genoveva, Varela Pérez, Lourdes Maria, Soria Escoms, Bernat, Martín Bermudo, Francisco:
Extra virgin olive oil ameliorates insulin resistance and beta cell function on high fat diets. Poster en Congreso. XXVIII Congreso Nacional de la Sociedad Española de Diabetes. Barcelona. 2017

Álvarez, Leticia, Luque, Amparo, Varela Pérez, Lourdes Maria, Martín Bermudo, Francisco:
Effects of fatty acids and polyphenols of extra virgin olive oil in a murine animal dietary model knockout for the LDL receptor. Poster en Congreso. I Congreso Nacional Biomedicina Jóvenes Investigadores en Valencia. Valencia. 2016

Álvarez, Leticia, Luque, Amparo, Varela Pérez, Lourdes Maria, Martín Bermudo, Francisco:
Efectos de los ácidos grasos y los polifenoles del aceite de oliva virgen extra en un modelo dietético murino con ausencia del receptor LDL. Poster en Congreso. XVII Reunión de la Sociedad Española de Nutrición en Santiago de Compostela y XXII Congreso de la Sociedad de Nutrición y Dietética de Galicia. Santiago de Compostela. 2016

Luque, Amparo, Álvarez, Leticia, Martín Bermudo, Francisco, Varela Pérez, Lourdes Maria:
A high fat diet based on extra virgin olive oil increased the atherosclerosis on LDLR-/- murine model. Poster en Congreso. XVII Reunión de la Sociedad Española de Nutrición en Santiago de Compostela y XXII Congreso de la Sociedad de Nutrición y Dietética de Galicia. Santiago de Compostela. 2016

Luque, Amparo, Álvarez, Leticia, Martín Bermudo, Francisco, Varela Pérez, Lourdes Maria:
Atherosclerosis disease was increased caused a high fat diet based on extra virgin olive oil in LDLR-/- murine model. Poster en Congreso. I Congreso Nacional Biomedicina Jóvenes Investigadores en Valencia. Valencia. 2016

Bermudez Pulgarin, Beatriz, Medina, Indira, Dahl, Tuva, Groeneweg, M, Holm, S, et. al.:
Intracellular NAMPT overexpression in hematopoietic cells attenuates atherosclerotic lesion development by regulating PPAR-gamma dependent monocyte differentiation and function. Poster en Congreso. 13th Dutch German Joint Meeting of the Molecular Cardiology Working Groups. Garmisch, Germany. 2015

Varela Pérez, Lourdes Maria, Casani, L, Camino, S, Vilahur, G, Badimon, L:
Role of inflammasomes and its regulation in the myocardium after ischemia-reperfusion. Poster en Congreso. 2nd Worl Congress on Acute Heart Failure 2015. Sevilla. 2015

Bermudez Pulgarin, Beatriz, Montserrat de la Paz, Sergio, Dahl, Tuva, Medina, Indira, Lopez Sergio, et. al.:
Intracellular NAMPT protects against atherosclerosis in a PPAR¿- dependent manner. Poster en Congreso. XXXIV Congreso Nacional de Farmacología SEF. Murcia, España. 2013

Varela Pérez, Lourdes Maria, Hoteit, C, Michel, Jb, Ho Tin Noé, B, Meilhac, o:
HDLs prevent hemorrhage induced by neutrophil elastase. Poster en Congreso. 81st European Atherosclerosis Society (EAS) Congress. Lyon, Francia. 2013

Tran Dinh, a, Varela Pérez, Lourdes Maria, Gilibert, S, Lapergue, B, Diallo, D, et. al.:
Endothelial SR-B1 limits cerebral infarction in a stroke model. Poster en Congreso. 81st European Atherosclerosis Society Congress. - Lyon, Francia. 2013

Bermudez Pulgarin, Beatriz, Dahl, Tb, Medina, I, Lopez Sergio, Varela Pérez, Lourdes Maria, et. al.:
Intracellular NAMPT protects against atherosclerosis in a PPARgamma-dependent manner. Poster en Congreso. XXXIV Congreso de la Sociedad Española de Farmacología. San Pedro del Pinatar (Murcia). 2013

Abia Gonzalez, María Rocío, Bermudez Pulgarin, Beatriz, Lopez Martin, Sergio, Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, et. al.:
Olive Oil Induces a Less Atherosclerotic Gene Expression Profile in Coronary Artery Smooth Muscle Cells Compared to Saturated Dietary Fats. Comunicación en congreso. II Congreso Internacional de Aceite de Oliva y Salud. Córdoba, Jaén. 2008. II Congreso Internacional de Aceite de Oliva y Salud (Cias¿08). 64. 64

Varela Pérez, Lourdes Maria:
Role of inflammasomes and its regulation in the myocardium after ischemia-reperfusion. Poster en Congreso

Varela Pérez, Lourdes Maria:
Role of inflammasomes and its regulation in the myocardium after ischemia-reperfusion. Poster en Congreso

Otras Publicaciones

Varela Pérez, Lourdes Maria:
El aceite de oliva virgen extra ayuda a reducir el riesgo de desarrollar enfermedad de hígado graso. Otras Publicaciones. 2017. Español

Varela Pérez, Lourdes Maria:
Investigadores demuestran que el aceite de oliva virgen extra puede revertir el daño hepático causado por una dieta alta en grasas. Otras Publicaciones. 2016. Español

Patentes:

Bermudez Pulgarin, Beatriz, Pedroche Jiménez, Justo Javier, Varela Pérez, Lourdes Maria, Ortega Gómez, Almudena, Lopez Sergio, et. al.:
Composición emulsionada de grasa saturada en agua, su preparación y utilización para la evaluación de la tolerancia a los triglicéridos. Patente de invención, Propiedad industrial. Solicitud: 2015-05-29

Lopez Martin, Sergio, Lucas Rodríguez, Ricardo, Ortega Gómez, Almudena, Varela Pérez, Lourdes Maria, Montserrat de la Paz, Sergio, et. al.:
Metabolitos de tirosol e hidroxitirosol. Patente de invención, Propiedad industrial. Solicitud: 2014-12-19